protein 1,352 words KG: GBA1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GBA1 (Glucocerebrosidase) Protein

🔬 Protein Info
Gene SymbolGBA1PROTEIN
Protein TypeHydrolase
Functionis a lysosomal hydrolase encoded by the GBA1 gene that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.
Subcellular Localization</th><td>Lysosome</td></tr>
Amino Acids536 aa
GeneCardsGBA1PROTEIN
Human Protein AtlasGBA1PROTEIN
Associated DiseasesALS, Aging, Alzheimer, Cancer, Gaucher Disease
Known Drugs/CompoundsBI-hTFR1, Bi-Htfr1, AAV5, AAV9, levodopa, rapamycin
InteractionsTFRC, LRRK2, JUN, TFR1, SNCA, MLKL
KG Connections435 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (15)

Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in