Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dementia with Lewy bodies: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurons | affects | cell_type | 0.80 |
| prefrontal cortex | affects | brain_region | 0.60 |
| locus coeruleus | affects | brain_region | 0.60 |
| substantia nigra | affects | brain_region | 0.60 |
| cortex | affects | brain_region | 0.60 |
| microglia | affects | cell_type | 0.60 |
| oligodendrocytes | affects | cell_type | 0.60 |
| synaptic plasticity | involves | pathway | 0.60 |
| hippocampus | affects | brain_region | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | implicated_in | gene | 1.00 |
| APOE-Ε4 | associated_with | gene | 0.80 |
| α-synuclein aggregation | associated_with | process | 0.70 |
| alpha-synuclein | causes | protein | 0.70 |
| PLCG2 | protects_against | gene | 0.60 |
| GBA | implicated_in | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| APP | modulates | gene | 0.60 |
| APP | treats | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| DDC | treats | gene | 0.60 |
| DDC | biomarker_for | gene | 0.60 |
| DDC | regulates | gene | 0.60 |
| DDC | colocalizes_in | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||