protein 1,867 words KG: HIF1APROTEIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsonsstate:published
Contents

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

🔬 Protein Info
Gene SymbolHIF
Full Name1α (Hypoxia-Inducible Factor 1-Alpha)
AliasesHIF1APROTEIN
Subcellular Localization</td><td>Nucleus, Cytoplasm</td></tr>
GeneCardsHIF
Human Protein AtlasHIF
Associated DiseasesAD, ALI, ALS, AMI, ARM
Known Drugs/Compoundsrapamycin, quercetin
InteractionsGAIN, IDH2, TKT, CANCER, TIGAR, AMPK
KG Connections1362 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Perinatal Hypoxia-Primed Microglia Targeting
Score: 0.38
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in