protein 1,315 words KG: HSPA8PROTEIN
Contents

Hsc70 Protein

🔬 Protein Info
Gene SymbolHSPA8PROTEIN
Full NameHsc70
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization</strong></td><td>Cytoplasm, nucleus, organelles</td></tr>\n <tr><td><strong>Protein Family</strong></td><td>Hsp70 fa
Molecular Weight71 kDa
UniProt IDSearch UniProt
GeneCardsHSPA8PROTEIN
Human Protein AtlasHSPA8PROTEIN
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Atherosclerosis, Cancer
Known Drugs/Compoundsrapamycin
InteractionsACAT1, ALPHA-SYNUCLEIN, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections495 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (11)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 4 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses

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