protein 3,473 words KG: HTTPROTEIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Huntingtin Protein (HTT)

🔬 Protein Info
Gene SymbolHTT
Full NameHuntingtin
Chromosome4p16.3.
Functionis a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Molecular Weight350 kDa
Amino Acids144 aa
Exons67
PathwaysAutophagy, Dna Repair
UniProt IDP42858
NCBI Gene ID3064
Ensembl IDENSG00000197393
OMIM143100
GeneCardsHTT
Human Protein AtlasHTT
GeneHTT (chromosome 4p16.3)
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, dimethyl fumarate, rapamycin
InteractionsP62, SQSTM1, TFEB, ULK1, MTOR, NFL
KG Connections699 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (9)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (2)

TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (3 edges)

HTTPROTEIN associated_with TREM2
HTTPROTEIN expressed_in TREM2
HTTPROTEIN protects_against TREM2