protein 610 words KG: IRAK4 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

IRAK4 Protein

🔬 Protein Info
Gene SymbolIRAK4
Chromosome15q15.4
Protein FamilyIL-1 receptor-associated kinases
Protein TypeSerine/Threonine Kinase
FunctionIRAK4 is a serine/threonine kinase essential for TLR/IL-1R signaling.
Molecular Weight52 kDa
Amino Acids460 aa
PathwaysNF-κB, MAPK signaling, NF-κB signaling, NF-κB pathway, NF-κB Signaling
UniProt IDQ9NWZ3
GeneCardsIRAK4
Human Protein AtlasIRAK4
Associated Diseasesneurodegeneration
InteractionsCSF2, IL1A, IRF3, TAK1, TLR4, TRAF6
KG Connections44 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (11)

Mitch A. Max
researcher · KG edge: debate_co_mention
Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: debate_co_mention

Knowledge Graph (12 edges)

IRAK4 expressed_in TAB1
IRAK4 expressed_in RELA
IRAK4 activates CSF2
IRAK4 activates IL1A
IRAK4 activates IRF3
IRAK4 activates TAK1
IRAK4 activates TLR4
IRAK4 activates TRAF6
IRAK4 debate_co_mention MAX
IRAK4 debate_co_mention MDM2