gene 1,922 words KG: TAB1
Contents

TAB1 — TAK1-Binding Protein 1

🧬 Gene Info
Gene SymbolTAB1
Full NameTAK1-Binding Protein 1
Chromosome11q13.1
Protein TypeAdaptor Protein
Functionis an adaptor protein that forms a critical complex with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1).
Subcellular Localizationboth cytoplasm and nucleus
Molecular Weight110 kDa
Amino Acids504 aa
PathwaysNF-κB, MAPK, TGF-β, MAPK pathway, MAPK signaling
UniProt IDQ61240
NCBI Gene ID10454
Ensembl IDENSG00000100994
OMIM602475
GeneCardsTAB1
Human Protein AtlasTAB1
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCANCER, CYTOKINES, IL1B, IL-6, INFLAMMATION, MAPK
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (9)

IL1B Gene - Interleukin 1 Beta
gene · KG edge: activates
MAPK1 Gene
gene · KG edge: activates
MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)
gene · KG edge: activates
MAPK3 Gene - ERK1
gene · KG edge: activates
NLRP6 - NLR Family Pyrin Domain Containing 6
gene · KG edge: facilitates_degradation_via_TRI

Knowledge Graph (12 edges)

TAB1 activates IL1B
TAB1 activates MAPK14
TAB1 binds TRAF6
TAB1 activates MAPK3
TAB1 activates MAPK1
TAB1 expressed_in RELA
IRAK4 expressed_in TAB1
P38 inhibits TAB1
NLRP6 facilitates_degradation_via_TRIM21 TAB1
TAB1 upstream_of NF-κB signaling

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