gene 1,811 words KG: RICTOR 2026-03-28
kind:genesection:genesstate:published
Contents

RICTOR Gene

🧬 Gene Info
Gene SymbolRICTOR
Full NameRaptor Companion
AliasesGIGYF1, AVO3, KIAA1999
Chromosome5p13.1
Functionencodes a critical component of the mechanistic target of rapamycin complex 2 (mTORC2), a key signaling hub that regulates cell survival, metabolism, cytoskeletal organization, and synaptic plastic...
Molecular Weight~200 kDa
Amino Acids708 aa
PathwaysmTOR, mtor, mTOR signaling, MAPK
UniProt IDQ6R327
NCBI Gene ID253782
Ensembl IDENSG00000164327
OMIM610027
GeneCardsRICTOR
Human Protein AtlasRICTOR
Protein Length1,718 amino acids
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsMTOR, PIK3C3, EGFR, PPARG, HSPA5, MAVS
KG Connections424 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
APC Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RICTOR phosphorylates RIPK1
RICTOR phosphorylates RPS6KB1
RICTOR phosphorylates RPTOR
RICTOR phosphorylates SQSTM1
RICTOR phosphorylates STAT3
RICTOR phosphorylates STING1
RICTOR phosphorylates TFE3
RICTOR phosphorylates TFEB
RICTOR interacts_with MTOR
RICTOR interacts_with PIK3C3