protein 894 words KG: LXRPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LXR Protein (Liver X Receptor)

🔬 Protein Info
Gene SymbolLXR
AliasesLiver X Receptor
PathwaysNF-κB
GeneCardsLXR
Human Protein AtlasLXR
IsoformGene
LXRαNR1H3
LXRβNR1H2
Gene VariantEffect
NR1H3 (LXRα) variantsAltered activity
NR1H2 (LXRβ) variantsModified function
ABCA1 variantsCholesterol efflux
RXRHeterodimer formation
PGC-1αCoactivator
NCoR/SMRTCorepressor
Associated DiseasesALS, Alzheimer, glioblastoma, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsPS1, SOAT1, TNF, MAPK, PKA, PI3K
KG Connections103 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses