protein 906 words KG: NESTIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Nestin Protein

🔬 Protein Info
Gene SymbolNESTIN
Chromosome1q23.1
Protein FamilyClass VI intermediate filaments
Functionis a protein encoded by the NES gene.
Primary Expressionneural stem and progenitor cells during development and in adult neurogenic regions[@reynolds1992]:
Subcellular LocalizationCytoplasm, intermediate filaments
Molecular Weight220 kDa
Amino Acids4477 aa
PathwaysCircadian Rhythm, Mapk, Mitochondrial Function, Wnt
UniProt IDP48681
NCBI Gene ID4756
Ensembl IDENSG00000132688
GeneCardsNESTIN
Human Protein AtlasNESTIN
Associated DiseasesNeurodevelopmental disorders, Brain tumors, Alzheimer's disease, Parkinson's disease, Stroke
InteractionsNOTCH1, GFAP, SOX2, PIK3R3, AKT, PI3K
KG Connections168 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Complement C1q Subtype Switching
Score: 0.44

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (11)

Dementia Australia
institution · KG edge: expressed_in
DLK2 — Delta-Like Non-Canonical Notch Ligand 2
gene · KG edge: expressed_in
DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1
gene · KG edge: inhibits
DCX Gene
gene · KG edge: activates
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

NESTIN expressed_in ALDH1L1
NESTIN expressed_in NOTCH1
NESTIN expressed_in DLK2
NESTIN expressed_in GFAP
NESTIN activates NOTCH1
NESTIN activates GFAP
NESTIN inhibits NOTCH1
NESTIN inhibits SOX2
NESTIN interacts_with PIK3R3
NESTIN inhibits AKT