gene

aldh1l1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aldh1l1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ALDH1L1
Full Name	Aldehyde Dehydrogenase 1 Family Member L1
Chromosome	3q21.3
Protein Type	Enzyme
Function	is a folate-metabolizing enzyme that catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate in the mitochondrial folate pathway.
Primary Expression	the liver and brain, particularly in astrocytes where it serves as a specific marker for mature astrocytes
Molecular Weight	99 kDa
Amino Acids	902 aa
UniProt ID	O75459
NCBI Gene ID	108
Ensembl ID	ENSG00000135917
OMIM	600182
GeneCards	ALDH1L1
Human Protein Atlas	ALDH1L1
Full-length ALDH1L1 (902 aa)	The canonical mitochondrial enzyme
Associated Diseases	Als, Frontotemporal Dementia, Glioma, Neuroinflammation, Tauopathy, Tumor
Interactions	DLK2, EGF, NESTIN, NOTCH1, SOX2, ASC
KG Connections	121 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: aldh1l1 — AlphaFold O75459 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ALDH1L1["ALDH1L1"]
    ALDH1L1 -->|"expressed in"| GFAP["GFAP"]
    ALDH1L1 -->|"expressed in"| ASTROCYTE["ASTROCYTE"]
    ALDH1L1 -->|"expressed in"| Als["Als"]
    ALDH1L1 -->|"expressed in"| ALS["ALS"]
    ALDH1L1 -->|"implicated in"| Tumor["Tumor"]
    ALDH1L1 -->|"implicated in"| Glioma["Glioma"]
    ALDH1L1 -->|"expressed in"| NOTCH1["NOTCH1"]
    ALDH1L1 -->|"expressed in"| DLK2["DLK2"]
    ALDH1L1 -->|"expressed in"| Neurogenesis["Neurogenesis"]
    SOX2["SOX2"] -->|"expressed in"| ALDH1L1
    EGF["EGF"] -->|"expressed in"| ALDH1L1
    GFAP -->|"expressed in"| ALDH1L1
    NESTIN["NESTIN"] -->|"expressed in"| ALDH1L1
    DLK2 -->|"expressed in"| ALDH1L1
    MERTK["MERTK"] -->|"expressed in"| ALDH1L1
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ALDH1L1
    VIMENTIN["VIMENTIN"] -->|"expressed in"| ALDH1L1
    GENES["GENES"] -->|"expressed in"| ALDH1L1
    NOTCH1 -->|"expressed in"| ALDH1L1

Outgoing (108)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
astrocyte	expressed_in	cell_type	0.80
GFAP	expressed_in	gene	0.70
ASTROCYTE	expressed_in	gene	0.70
Als	expressed_in	disease	0.65
Als	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	implicated_in	disease	0.65
Glioma	implicated_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Dementia	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Tauopathy	associated_with	disease	0.65
astrocytes	expressed_in	cell_type	0.65
NOTCH1	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
NESTIN	expressed_in	gene	0.60
DLK2	inhibits	gene	0.60
EGF	inhibits	gene	0.60
NESTIN	inhibits	gene	0.60
NOTCH1	inhibits	gene	0.60
SOX2	inhibits	gene	0.60
EGF	expressed_in	gene	0.60
VIMENTIN	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
S100B	expressed_in	gene	0.60
ASC	activates	gene	0.60
NLRP3	activates	gene	0.60
GFAP	activates	gene	0.60
AQP4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
CHOP	expressed_in	gene	0.60
IL6	expressed_in	gene	0.60
Ependymal	expressed_in	cell_type	0.60
CD8	associated_with	gene	0.60
CD4	associated_with	gene	0.60
TAU	associated_with	gene	0.60
IBA1	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
AQP4	biomarker_for	gene	0.60
Neurogenesis	expressed_in	pathway	0.60
Notch	expressed_in	pathway	0.60
GENES	expressed_in	gene	0.60

Incoming (20)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
SOX2	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
NESTIN	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
MERTK	expressed_in	gene	0.60
VIMENTIN	expressed_in	gene	0.60
NOTCH1	expressed_in	gene	0.60
AQP4	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
GFAP	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
ROS	activates	gene	0.60
NOTCH	expressed_in	gene	0.60
FTLD	associated_with	gene	0.60
TAUOPATHY	associated_with	gene	0.60
benchmark_ot_ad_answer_key:ALDH1L1	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

aldh1l1

Understanding Entity Pages

Wiki Pages (21)

ALDH1L1

Astrocyte Reactivity Mechanism

Astrocytes

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Astrocyte Metabolic Enhancement Therapy for PD

Zombosomes — Anucleated Cell Couriers in Alpha-Synuclein Propagation

Astrocytes in Neurodegeneration

Tripartite Synapse

Cell Type Atlas

Brain Region Therapeutic Targeting Index

Telencephalon Development

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

Astrocyte Glutamate-Buffer Rescue with EAAT2 Transcription Reboot

Astrocyte Dysfunction: AD vs PD vs ALS vs FTD vs HD Comparison

Astrocyte-to-Neuron Reprogramming Therapy

Animal Models of Corticobasal Syndrome

Single Cell Genomics in Neurodegeneration

Astrocytes in Brain Homeostasis

Astroglia (Astrocytes)

Nigral Astrocytes

Locus Coeruleus Astrocytes