| Gene Symbol | PGC |
| Full Name | 1 Alpha |
| Aliases | PPARGC1APROTEIN |
| Target Class | Transcription Factor |
| Function | Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Mechanism of Action | Small molecule modulator of transcriptional coactivator function |
| Subcellular Localization | | Nucleus, Mitochondrion |
| Druggability | Low (0.43) |
| Clinical Stage | Approved |
| GeneCards | PGC |
| Human Protein Atlas | PGC |
| Associated Diseases | ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, CANCER |
| Known Drugs/Compounds | reactive oxygen species, THYROID_HORMONE, Aloe-emodin, Kaixinsan, glitazones, piperine |
| Interactions | PRKAA1, ATG10, SIRT1, DNM1L, BAX, LC3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito |
| KG Connections | 992 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |