concept

NAD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1169Connections
5Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

NAD is a concept in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with AD, ADH, ALI. Connected to 546 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameNAD
SummaryBiotechnology company specializing in NAD+ precursors and anti-aging research, developing nicotinamide riboside (NR) for neurodegenerative diseases
Key Genes/ProteinsAGING, SIRT1, MITOCHONDRIA
Related DiseasesAging, Inflammation, Als, Cancer, Obesity
Linked Hypotheses6 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

ChromaDex

company · 924 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Pathway Diagram

graph TD
    NAD["NAD"]
    NAD -->|"regulates"| neuronal_bioenergetics["neuronal bioenergetics"]
    NAD -->|"regulates"| oxidative_stress["oxidative stress"]
    NAD -->|"regulates"| epigenetic_changes["epigenetic changes"]
    NAD -->|"regulates"| Tumor["Tumor"]
    NAD -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NAD -->|"regulates"| Cancer["Cancer"]
    NAD -->|"regulates"| Autoimmune["Autoimmune"]
    NAD -->|"activates"| Aging["Aging"]
    NAD -->|"regulates"| Cardiovascular["Cardiovascular"]
    NAD -->|"causes"| Inflammation["Inflammation"]
    cd38["cd38"] -->|"regulates"| NAD
    P7C3_A20["P7C3-A20"] -->|"activates"| NAD
    ATP["ATP"] -->|"causes"| NAD
    CD38["CD38"] -->|"regulates"| NAD
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"] -->|"regulates"| NAD
    DNA["DNA"] -->|"contributes to"| NAD
    SIRT6["SIRT6"] -->|"inhibits"| NAD
    EGR2["EGR2"] -->|"inhibits"| NAD
    PARP1["PARP1"] -->|"inhibits"| NAD

Outgoing (881)

TargetRelationTypeStr
AGINGactivatesgene1.00
Agingactivatesdisease1.00
SIRT1regulatesgene1.00
Inflammationactivatesdisease1.00
SIRT1associated_withgene1.00

Incoming (288)

SourceRelationTypeStr
nicotinamidetargetsdrug0.85
P7C3-A20activatesdrug0.70
AGINGassociated_withgene0.70
CD38implicated_ingene0.70
ATPreleasesgene0.70

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D 0.614 neurodegeneration What is the molecular mechanism by which
Senescence-Activated NAD+ Depletion Rescue 0.604 neurodegeneration Senolytic therapy for age-related neurod
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove 0.592 neurodegeneration Epigenetic reprogramming in aging neuron
Mitochondrial NAD+ Salvage Enhancement 0.426 neurodegeneration Gene expression changes in aging mouse b
SIRT6-NAD+ Axis Enhancement Therapy 0.395 neurodegeneration Epigenetic clocks and biological aging i

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317] Velma GR, Krider IS, Alves ETM, Courey J J Med Chem 2024 1
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X Theranostics 2023 1
Assessing the Status of Mandatory Tuberculosis Case Notification among Private P [PMID:35068738] Duggal K, Elsy M, Majella MG, Akkilagunt Indian J Community Med 2021 1
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic [PMID:33888596] Yoshino M, Yoshino J, Kayser BD, Patti G Science 2021 1
NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] Navas LE, Carnero A Signal Transduct Target Ther 2021 1
Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. [PMID:33377090] Dowling P, Gargan S, Zweyer M, Henry M, STAR Protoc 2020 1
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity [PMID:30193097] Latorre-Muro P, Baeza J, Armstrong EA, H Mol Cell 2018 1
NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980] Gerner RR, Klepsch V, Macheiner S, Arnha Gut 2018 1
The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcin [PMID:28329682] Nargund AM, Pham CG, Dong Y, Wang PI, Os Cell Rep 2017 1
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PMID:26686024] Wiley CD, Velarde MC, Lecot P, Liu S, Sa Cell Metab 2016 1
NAD+ and sirtuins in aging and disease. [PMID:24786309] Imai S, Guarente L Trends Cell Biol 2014 1
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107] Lan T, Shang D, Lin L, Wang H, Zou J et Autophagy 2026 0
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] Fazal F, Dar NJ, Ahamad S, Khan S, Bano Mol Aspects Med 2026 0
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] Lu C, Wang W, Fu YX Nat Rev Cancer 2026 0
CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Vi [PMID:41487094] Hu D, Lin Y, Huang H, Xian G, Chen Y et Circ Res 2026 0
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] Li D, Cui G, Yang K, Lu C, Jiang Y et al Nat Cell Biol 2026 0
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] Solomon J, Mandal S, Aran KR Gene 2026 0
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] Li L, Ye Q, Ma J, Wang Z, Liu T et al. Cancer Cell 2026 0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] Qin H, Yang L, Du J, Xu X, Chen Z et al. Int Immunopharmacol 2026 0
EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749] Zhang Q, Abudukadier A, Chen H, Xiong L, Microbiol Spectr 2026 0