| Gene Symbol | SLC1A1 |
| Aliases | SLC1A1PROTEIN |
| Protein Type | Transporter |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | pyramidal neurons and medium spiny neurons - Glia: Low expression in astrocytes compared to EAAT1 (GL |
| Molecular Weight | 57 kDa |
| GeneCards | SLC1A1 |
| Human Protein Atlas | SLC1A1 |
| Glutamate | Primary substrate |
| Aspartate | Alternative substrate |
| Cystine | In exchange for glutamate (system Xc-) |
| Glutamate clearance | Impaired in epileptic tissue |
| Excitotoxicity | Glutamate-induced neuronal damage |
| Therapeutic targeting | Modulators under investigation |
| Synaptic function | Altered glutamate recycling |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson |
| Interactions | CACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB2 |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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