protein 1,084 words KG: SPG11 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SPG11 Cytoskeletal Protein

🔬 Protein Info
Gene SymbolSPG11
AliasesPage for SPG11 Gene
Chromosome10p14
Functionis a large cytoplasmic protein encoded by the SPG11 gene located on chromosome 15q21.
Primary ExpressionPredominantly neuronal
Molecular Weight~300 kDa
Amino Acids163 aa
Exons40
UniProt IDQ96MC7
NCBI Gene ID80208
GeneCardsSPG11
Human Protein AtlasSPG11
FeatureValue
Protein Length2,133 amino acids
InheritanceAutosomal Recessive
Associated DiseasesInflammation, Neuroinflammation, neurodegeneration
InteractionsMICROGLIA, NEURODEGENERATION
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
R-Loop Resolution Enhancement Therapy
Score: 0.43

Related Analyses (7)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (6)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: implicated_in
SPG15 Gene - Spastic Paraplegia 15
gene · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: implicated_in
Microglia in Neurodegeneration
entity · KG edge: activates
Neurodegeneration
disease · KG edge: inhibits

Knowledge Graph (12 edges)

SPG11 associated_with SPG15
SPG11 associated_with TAF15
SPG11 associated_with TARDBP
SPG11 associated_with VAPB
SPG11 associated_with VCP
SPG11 associated_with neurodegeneration
SPG11 associated_with NEUROINFLAMMATION
SPG11 associated_with Neuroinflammation
SPG11 inhibits Neurodegeneration
SPG11 associated_with Inflammation