protein 1,185 words KG: SQSTM1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

SQSTM1/p62 Protein

🔬 Protein Info
Gene SymbolSQSTM1
Full NameSQSTM1/p62
Chromosome5q35.3.
Protein TypeProtein
Functionp62/SQSTM1 functions as: [@jones2021]
Molecular Weight~62 kDa (hence p62)
PathwaysAdaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt IDQ13501
GeneCardsSQSTM1
Human Protein AtlasSQSTM1
Associated DiseasesAD, ADH, ALI, ALS, AMI, ARM
Known Drugs/CompoundsUbiquitinated Proteins, Ubiquitinated Cargo, Ubiquitinated Substrates, RAPAMYCIN, STOCK1N-57534, ATC161
InteractionsABCA1, APOE, LOX, NDP52, TAX1BP1, FUS
KG Connections4026 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (7)

What determines the spatial organization of autophagy recept
neurodegeneration · failed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in