| Gene Symbol | TFAM |
| Chromosome | 10q21.1 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | Drugs targeting TFAM would enhance or modulate its transcriptional activity to increase mitochondrial DNA replication and gene expression, thereby boosting mitochondrial biogenesis and ATP producti... |
| Mechanism of Action | Drugs targeting TFAM would enhance or modulate its transcriptional activity to increase mitochondrial DNA replication and gene expression, thereby boosting mitochondrial biogenesis and ATP production. Alternatively, indirect approaches activate upstream regulators like PGC-1α and SIRT1 to increase TFAM expression and activity. |
| Subcellular Localization | Mitochondria (mitochondrial matrix) |
| Druggability | Medium (0.50) |
| Clinical Stage | Approved |
| Molecular Weight | ~29 kDa |
| Amino Acids | 246 aa |
| Exons | 9 |
| Pathways | Apoptosis, Ferroptosis, Metastasis, Mitochondrial Function, Mitophagy |
| UniProt ID | Q00059 |
| GeneCards | TFAM |
| Human Protein Atlas | TFAM |
| Associated Diseases | ALS, ALZHEIMER, Aging, Carcinoma, INFLAMMATION |
| Known Drugs/Compounds | Cytoplasmic Mitochondrial DNA, Mitochondrial DNA, Mitochondrial Dna, Cytoplasmic Mitochondrial Dna, resveratrol, RAPAMYCIN |
| Interactions | HK2, LC3, SIRT3, EGFR, NRF1, NRF2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | TFAM overexpression creates mitochondrial donor-re |
| KG Connections | 837 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |