Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MITOCHONDRIAL DNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 869 entities in the SciDEX knowledge graph.
| Gene Symbol | MITOCHONDRIAL DNA |
| Primary Expression | Spinal Cord, Substantia Nigra, Hippocampus |
| Pathways | Mitophagy, CGAS-STING, Autophagy, Cgas/Sting Dna Sensing Pathway, Nf-Κb |
| Associated Diseases | ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia |
| Interactions | IL1B, DAPK1, HMGCR, GENES, PARP1, TNF |
| KG Connections | 1263 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated"| Alzheimer["Alzheimer"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated"| Als["Als"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"interacts"| Tumor["Tumor"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Als_1["Als"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Inflammation["Inflammation"]
DHCR24["DHCR24"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
EIF2AK2["EIF2AK2"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
LMNA["LMNA"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
STING["STING"] -->|"activates"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
style MITOCHONDRIAL_DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| DNA | associated_with | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| MTDNA | associated_with | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| MITOCHONDRIA | associated_with | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| DNA | causes | gene | 1.00 |
| MTDNA | causes | gene | 1.00 |
| Inflammation | associated_with | disease | 0.95 |
| Als | inhibits | disease | 0.95 |
| Tumor | activates | disease | 0.95 |
| Cancer | therapeutic_target | disease | 0.95 |
| Parkinson | activates | disease | 0.95 |
| Autophagy | activates | pathway | 0.90 |
| AUTOPHAGY | activates | gene | 0.90 |
| DRP1 | activates | gene | 0.90 |
| Aging | activates | disease | 0.85 |
| Alzheimer | activates | disease | 0.85 |
| Neuroinflammation | activates | disease | 0.85 |
| Cancer | associated_with | disease | 0.85 |
| Diabetes | activates | disease | 0.85 |
| Aging | therapeutic_target | disease | 0.85 |
| Alzheimer | therapeutic_target | disease | 0.85 |
| Aging | associated_with | disease | 0.85 |
| Nf-Κb | activates | pathway | 0.80 |
| Oxidative Stress | inhibits | pathway | 0.80 |
| Mitochondrial Function | inhibits | pathway | 0.80 |
| DNA | interacts_with | gene | 0.80 |
| Immune Response | activates | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| TDP43 | causes | entity | 0.90 |
| OXIDATIVE STRESS | activates | gene | 0.90 |
| ROS | activates | gene | 0.90 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.80 |
| PARKINSON'S DISEASE | activates | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.80 |
| NF-ΚB | activates | gene | 0.80 |
| ROS | therapeutic_target | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | causes | gene | 0.80 |
| AMPK | inhibits | gene | 0.70 |
| MITOPHAGY | therapeutic_target | gene | 0.70 |
| INFLAMMATION | interacts_with | gene | 0.70 |
| PYROPTOSIS | activates | gene | 0.70 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.70 |
| CYTOKINES | activates | gene | 0.70 |
| MITOPHAGY | inhibits | gene | 0.70 |
| INFLAMMATION | regulates | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.70 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.70 |
| DNA | associated_with | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| AUTOPHAGY | activates | gene | 0.70 |
| FERROPTOSIS | inhibits | gene | 0.70 |
| INFLAMMATION | inhibits | gene | 0.70 |
| PARKINSON | activates | gene | 0.70 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.70 |
| PARKINSON | interacts_with | gene | 0.70 |
| SIRT1 | activates | gene | 0.70 |
| POLG | activates | gene | 0.70 |
| ALZHEIMER | implicated_in | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | implicated_in | gene | 0.70 |
| AMYLOID | implicated_in | gene | 0.70 |
| ALZHEIMER | therapeutic_target | gene | 0.70 |
| ROS | causes | gene | 0.70 |
| NEURODEGENERATION | causes | gene | 0.70 |
| AIM2 | activates | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.70 |
| APOPTOSIS | associated_with | gene | 0.70 |
| OXIDATIVE STRESS | inhibits | gene | 0.70 |
| ROS | treats | gene | 0.70 |
| DHCR24 | interacts_with | gene | 0.60 |
| EIF2AK2 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu | 0.580 | neurodegeneration | What are the mechanisms by which gut mic |
| Senescent Cell Mitochondrial DNA Release | 0.545 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757] | ["Bi D", "Yang X", "Wang Y", "Yong J", " | Frontiers in immunology | 2026 | 0 |
| Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577] | ["Zhou R", "Lin X", "Liao Z", "Lin J", " | Ageing research reviews | 2026 | 0 |
| Role of NEIL1 in genome maintenance. [PMID:40010204] | ["McCullough A", "Minko I", "Luzadder M" | DNA repair | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808] | ["Lai P", "Liu L", "Bancaro N", "Troiani | Immunity | 2025 | 0 |
| Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559] | ["Akgun Y"] | Ageing research reviews | 2025 | 0 |
| Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226] | ["Daubermann C", "Herhaus B", "Neuberger | Molecular biology reports | 2025 | 0 |
| Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587] | ["Song Z", "Xie X", "Chen Y", "Zhang B", | Immunity | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604] | ["Orlikova-Boyer B", "Lorant A", "Gajula | Biomarker research | 2024 | 0 |
| Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919] | ["Li X", "Liu Y", "Ke J", "Wang Z", "Han | Advanced materials (Deerfield | 2024 | 0 |
| The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400] | Zhang Y, Zou M, Wu H, Zhu J, Jin T | Neurobiology of disease | 2024 | 0 |
| mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044] | ["Li Y", "Cui J", "Liu L", "Hambright W" | Cell death & disease | 2024 | 0 |
| Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958] | ["Byrns C", "Perlegos A", "Miller K", "J | Nature | 2024 | 0 |
| Apoptotic stress causes mtDNA release during senescence and drives the SASP. [PMID:37821702] | ["Victorelli S", "Salmonowicz H", "Chapm | Nature | 2023 | 0 |
| Exposome and unhealthy aging: environmental drivers from air pollution to occupa [PMID:37688657] | Pandics T, Major D, Fazekas-Pongor V, Sz | GeroScience | 2023 | 0 |
| cGAS-STING drives ageing-related inflammation and neurodegeneration. [PMID:37532932] | Gulen MF, Samson N, Keller A, Schwabenla | Nature | 2023 | 0 |
| Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STI [PMID:36964253] | ["Kim J", "Kim H", "Chung J"] | Experimental & molecular medic | 2023 | 0 |
| The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse [PMID:37633968] | ["Jiang S", "Tian T", "Yao H", "Xia X", | Cell death and differentiation | 2023 | 0 |