| Gene Symbol | TRPV1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 1 |
| Chromosome | 17p13.2 |
| Protein Type | Protein |
| Function | TRPV1 is a capsaicin-activated ion channel that responds to heat and pain stimuli. |
| Primary Expression | sensory neurons (dorsal root ganglion, trigeminal ganglion), where it functions as a polymodal nociceptor activated by[@caterina2 |
| Pathways | Autophagy |
| UniProt ID | [Q9Y5Q1](https://www.uniprot.org/uniprotkb/Q9Y5Q1/entry) |
| GeneCards | TRPV1 |
| Human Protein Atlas | TRPV1 |
| Ankyrin Repeat Domain (ARD) | Six ankyrin repeats in the N-terminus for protein interactions |
| S1-S4 domain | Voltage-sensor-like domain that responds to ligands |
| S5-S6 pore domain | Forms the ion conduction pathway |
| Vanilloid binding pocket | Hydrophobic pocket for capsaicin and resiniferatoxin binding |
| Thermal stimuli | Noxious heat (>43°C) |
| Associated Diseases | Cancer, Ovarian Cancer |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE3, APOE4, APOPTOSIS |
| KG Connections | 235 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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