| Gene Symbol | TSC2PROTEIN |
| Function | is a tumor suppressor protein that forms a heterodimeric complex with TSC1 (hamartin) to regulate mTORC1 signaling. |
| Subcellular Localization | | | Lysosomal recruitment | Complex localizes to lysosomes for Rheb regulation | |
| Molecular Weight | 198 kDa |
| GeneCards | TSC2PROTEIN |
| Human Protein Atlas | TSC2PROTEIN |
| N-terminal domain | TSC1-binding region |
| GAP domain (Rhodanese homology domain) | GTPase-activating protein function |
| Transactivation domain | C-terminal region for transcriptional regulation |
| Multiple phosphorylation sites | For regulation by kinases including AKT, AMPK, and GSK3β |
| Growth factor signaling | PI3K/AKT phosphorylates and inhibits TSC2 |
| Energy sensing | AMPK activates TSC2 during energy stress |
| Nutrient sensing | Amino acids activate mTORC1 independently of TSC |
| Autophagy impairment | TSC2/mTOR affects alpha-synuclein clearance |
| Lysosomal function | TSC2 regulates lysosomal biogenesis |
| Associated Diseases | ALS, Diabetes, epilepsy, Ms, neurodegeneration, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACETYL-COA, ACTB, Akt, AKT, AKT1, AKT3 |
| KG Connections | 346 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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