| Gene Symbol | TSC2PROTEIN |
| Function | is a tumor suppressor protein that forms a heterodimeric complex with TSC1 (hamartin) to regulate mTORC1 signaling. |
| Subcellular Localization | |
| Lysosomal recruitment | Complex localizes to lysosomes for Rheb regulation | |
| Molecular Weight | 198 kDa |
| GeneCards | TSC2PROTEIN |
| Human Protein Atlas | TSC2PROTEIN |
| GAP activity | TSC2 activates GTP hydrolysis on Rheb, inhibiting mTORC1 |
| Complex stability | TSC1 stabilizes TSC2 and facilitates its localization |
| Lysosomal recruitment | Complex localizes to lysosomes for Rheb regulation |
| Associated Diseases | ALS, Diabetes, Ms, Parkinson, epilepsy, neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | EGF, TFEB, MTOR, AKT, LC3, TSC1 |
| KG Connections | 347 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |