protein 1,023 words KG: VDAC2PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

VDAC2 — Voltage-Dependent Anion Channel 2 Protein

🔬 Protein Info
Gene SymbolVDAC2
Full NameVoltage-Dependent Anion Channel 2 Protein
AliasesVoltage-Dependent Anion Channel 2
Chromosome10q22.2
Protein FamilyPorin/VDAC family (eukaryotic)
Function### Mitochondrial Metabolite Transport
Primary ExpressionUbiquitous, high in brain, heart, skeletal muscle
Subcellular LocalizationMitochondrial outer membrane
Molecular Weight31.6 kDa
Amino Acids294 aa
PathwaysAutophagy, autophagy pathway, epigenetic regulation, mitophagy, oxidative stress response
UniProt IDP45880
NCBI Gene ID7417
Ensembl IDENSG00000165637
OMIM193245
GeneCardsVDAC2
Human Protein AtlasVDAC2
Associated DiseasesCancer, Cardiovascular, Inflammation, Ischemia, Ms, Neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsBAX, TFEB, PRKN, GAIN, DMT1, CYBB
KG Connections215 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in