| Gene Symbol | SMAD4 |
| Full Name | SMAD Family Member 4 |
| Chromosome | 18q21.1 |
| Function | is a central mediator of TGF-beta signaling in the nervous system. |
| Molecular Weight | 60 kDa |
| Amino Acids | 552 aa |
| Pathways | TGF-β |
| UniProt ID | Q99707 |
| NCBI Gene ID | 4089 |
| Ensembl ID | ENSG00000141646 |
| OMIM | 600993 |
| GeneCards | SMAD4 |
| Human Protein Atlas | SMAD4 |
| MH1 domain (N-terminal) | Contains the DNA-binding domain that recognizes SMAD-binding elements (SBE) in target gene promoters |
| MH2 domain (C-terminal) | Mediates protein-protein interactions with R-SMADs, transcriptional co-activators, and co-repressors |
| Associated Diseases | Cancer |
| Interactions | ACSL4, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS, App |
| KG Connections | 198 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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