gene 890 words KG: SMAD2 2026-03-24
kind:genesection:genesstate:published
Contents

SMAD2 Gene

🧬 Gene Info
Gene SymbolSMAD2
Full NameSMAD Family Member 2
Chromosome18q21.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization(cytoplasmic vs. nuclear) is dynamically regulated by TGF-beta signaling[@schilling2008]
Amino Acids467 aa
PathwaysTGF-β, TGF-β signaling, TGF-β Signaling
UniProt IDQ99716
NCBI Gene ID4092
Ensembl IDENSG00000175387
OMIM601023
GeneCardsSMAD2
Human Protein AtlasSMAD2
Associated DiseasesAging, Als, Alzheimer, Cancer, Colorectal Cancer, Tumor
Known Drugs/Compoundslycopene, APIGENIN
InteractionsLC3, AKT, BNIP3L, STAT1, FOXO1, BNIP3
KG Connections266 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Ocular Immune Privilege Extension
Score: 0.47
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
MAP1LC3A Gene
gene · KG edge: activates
FUNDC1 — FUN14 Domain Containing 1
gene · KG edge: activates

Knowledge Graph (12 edges)

SMAD2 expressed_in LC3
SMAD2 activates LC3
SMAD2 expressed_in P62
SMAD2 activates AKT
SMAD2 expressed_in SQSTM1
SMAD2 expressed_in SMAD3
SMAD2 expressed_in PRKN
SMAD2 expressed_in PINK1
SMAD2 activates BNIP3L
SMAD2 regulates SMAD4