gene 849 words KG: FUNDC1 2026-03-24
kind:genesection:genesstate:published
Contents

FUNDC1 — FUN14 Domain Containing 1

🧬 Gene Info
Gene SymbolFUNDC1
Full NameFUN14 Domain Containing 1
Chromosome5q33.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight17 kDa
Amino Acids156 aa
Gene TypeProtein coding
PathwaysApoptosis, Autophagy, Ferroptosis, Lipid Metabolism, Metastasis
UniProt IDQ8IWV1
NCBI Gene ID87178
Ensembl IDENSG00000077616
OMIM606467
GeneCardsFUNDC1
Human Protein AtlasFUNDC1
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer's disease
InteractionsAMBRA1, PINK1, BCL2L13, NLRP3, ABCD3, FIP200
KG Connections951 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Phase-Separated Organelle Targeting
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

FUNDC1 activates G3BP1
FUNDC1 activates GBA
FUNDC1 activates HIF1A
FUNDC1 activates JNK
FUNDC1 activates LGALS3
FUNDC1 activates LMNA
FUNDC1 activates MAP1LC3B
FUNDC1 activates MAPK8
FUNDC1 activates MFN1
FUNDC1 activates MIRO1