| Gene Symbol | TAU |
| Chromosome | 17q21.31 |
| Protein Family | MAPT family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, where they bind to microtubules and promote their polymerization and stability |
| Subcellular Localization | Axons, Neurons |
| Molecular Weight | 45-65 kDa (isoform dependent) |
| Amino Acids | 441 aa |
| Pathways | Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology |
| GeneCards | TAU |
| Human Protein Atlas | TAU |
| N-terminal Projection Domain | This region projects away from the microtubule surface and interacts with neuronal plasma membrane components, neural stem cells, and other cytoskeletal elements. |
| Proline-Rich Domain | Contains multiple PXXP motifs that interact with SH3 domain-containing proteins involved in signaling pathways. |
| Phosphorylation | The most extensively studied modification, with over 80 potential phosphorylation sites identified. Hyperphosphorylation reduces microtubule binding and promotes aggregation. |
| Acetylation | Regulates tau aggregation and can be detected in AD brain tissue. |
| Associated Diseases | AD, Aging, Als, Alzheimer, Alzheimer Disease |
| Known Drugs/Compounds | 12A12, Disease-modifying therapy, DONANEMAB, DONEPEZIL, Flavonoids, Hyperbaric Oxygen Therapy |
| Interactions | AB, ABCA1, ABCA7, ABI3, ACE, ACE2 |
| SciDEX Hypotheses | TREM2 should remain under review until replicated APOE should remain under review until replicated GFAP should remain under review until replicated (+2 more) |
| KG Connections | 5366 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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