| Gene Symbol | ULK2 |
| Full Name | Unc-51 Like Kinase 2 |
| Chromosome | 17p11.2 |
| Function | ULK2 orchestrates autophagy initiation through a sophisticated cascade of protein interactions and phosphorylation events |
| Primary Expression | both excitatory and inhibitory neurons |
| Molecular Weight | 105 kDa |
| Pathways | mTOR, mtor, AMPK, PI3K |
| UniProt ID | [Q8IYT8](https://www.uniprot.org/uniprot/Q8IYT8) |
| Ensembl ID | ENSG00000107485 |
| GeneCards | ULK2 |
| Human Protein Atlas | ULK2 |
| [mTOR](/entities/mtor) sensing | ULK2 is inhibited by mTORC1 under nutrient-rich conditions; mTORC1 phosphorylates ULK2 at multiple sites to suppress autophagy initiation[@egan2011] |
| AMPK activation | Energy stress activates AMPK, which directly phosphorylates ULK2 at Ser317 and Ser777 to stimulate autophagy[@gwinn2008] |
| Phosphorylation targets | ULK2 phosphorylates multiple autophagy proteins including Beclin-1, Vps34, and ATG14 to promote autophagosome nucleation[@russell2013] |
| Neuronal autophagy | Critical for neuronal protein quality control, clearing misfolded proteins and damaged organelles[@button2014] |
| Associated Diseases | Als, Alzheimer, Inflammation |
| Interactions | ALZHEIMER, AMPK, APOE, APP, CALB1, CCT4 |
| KG Connections | 109 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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