Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 108 pages matching "chai"

📊 CSF Neurofilament Light Chain (NfL) in NeurodegenerationKG

biomarker · 4,443 words · 278 hyp41 ana162 exp

⚙️ Gene-Mechanism-Therapy Causal ChainsKG

mechanism · 4,075 words · 104 hyp52 ana21 exp

⚙️ GBA1→GCase→Lysosome→PD Causal ChainKG

mechanism · 3,927 words · 14 hyp35 ana10 exp

🔀 SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal ChainKG

pathway · 3,707 words · 19 hyp37 ana27 exp

⚙️ TREM2→Microglial Dysfunction→Alzheimer's Disease Causal ChainKG

mechanism · 3,665 words · 93 hyp66 ana90 exp

⚙️ pink1-parkin-mitophagy-pd-causal-chainKG

mechanism · 3,341 words · 19 hyp36 ana18 exp

⚙️ VPS35 Retromer Dysfunction Parkinson's Disease Causal ChainKG

mechanism · 3,215 words · 6 hyp43 ana60 exp

🔬 Kinesin-1 Heavy Chain ProteinKG

protein · 3,164 words · 8 hyp6 ana

🔀 APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal ChainKG

pathway · 3,076 words · 60 hyp55 ana95 exp

⚙️ C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal ChainKG

mechanism · 3,056 words · 22 hyp60 ana47 exp

⚙️ SOD1 Superoxide Dismutase 1 ALS Causal ChainKG

mechanism · 3,026 words · 10 hyp50 ana39 exp

⚙️ MAPT→Tau→Aggregation→PSP Causal ChainKG

mechanism · 3,015 words · 16 hyp36 ana28 exp

📊 p-Tau Biomarker in Immunoglobulin Light Chain and Transthyretin AmyloidosisKG

biomarker · 2,836 words · 16 hyp5 ana15 exp

⚙️ RAB39B Endosomal-Lysosomal Dysfunction PD Causal ChainKG

mechanism · 2,779 words · 18 hyp36 ana7 exp

⚙️ FUS Gene-Mechanism-Therapy Causal Chain — ALS/FTDKG

mechanism · 2,751 words · 54 hyp62 ana30 exp

⚙️ HTT Gene-Mechanism-Therapy Causal Chain — Huntington's DiseaseKG

mechanism · 2,745 words · 53 hyp56 ana15 exp

⚙️ GRN Progranulin FTD Causal ChainKG

mechanism · 2,744 words · 32 hyp42 ana25 exp

🔬 Neurofilament Heavy Chain (NF-H)KG

protein · 2,736 words · 2 hyp2 ana

🔬 Neurofilament Light Chain (NFL)KG

protein · 2,636 words · 58 hyp23 ana6 exp

🧬 KLC1 — Kinesin Light Chain 1KG

gene · 2,601 words · 13 hyp3 ana

⚙️ VCP→TDP-43→ALS/FTD Causal ChainKG

mechanism · 2,601 words · 11 hyp55 ana37 exp

⚙️ TREM2 Gene-Mechanism-Therapy Chain — From Genetic Risk to Therapeutic TargetKG

mechanism · 2,576 words · 125 hyp74 ana42 exp

🔀 SNCA→Alpha-synuclein→Parkinson's Disease Causal ChainKG

pathway · 2,538 words · 10 hyp42 ana83 exp

🧬 NFM — Neurofilament Medium ChainKG

gene · 2,470 words · 1 ana5 exp

🧬 MYH8 (Myosin Heavy Chain 8)KG

gene · 2,361 words · 1 hyp1 ana

⚙️ OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal ChainKG

mechanism · 2,356 words · 150 hyp58 ana39 exp

🧬 C1QA Gene — Complement Component 1q A ChainKG

gene · 2,340 words · 84 hyp28 ana32 exp

⚙️ Short Chain Fatty Acids in NeurodegenerationKG

mechanism · 2,335 words · 283 hyp52 ana74 exp

⚙️ LRRK2→Kinase→Autophagy→PD Causal ChainKG

mechanism · 2,325 words · 13 hyp37 ana27 exp

⚙️ ATP13A2 Lysosomal Dysfunction Parkinson's Disease Causal ChainKG

mechanism · 2,302 words · 22 hyp44 ana64 exp

⚙️ PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal ChainKG

mechanism · 2,255 words · 45 hyp46 ana5 exp

🧬 DYNLT1 — Dynein Light Chain Tctex-Type 1KG

gene · 2,182 words · 4 hyp2 ana1 exp

⚙️ Short-Chain Fatty Acid Therapy for Neurodegenerative DiseasesKG

mechanism · 2,090 words · 178 hyp66 ana18 exp

🧬 DYNC1LI1 — Dynein Cytoplasmic 1 Light Intermediate Chain 1KG

gene · 2,059 words · 2 hyp2 ana

🧬 CYP11A1 Gene - Cholesterol Side-Chain Cleavage EnzymeKG

gene · 2,028 words · 11 hyp6 ana13 exp

⚙️ PSEN2 Presenilin 2 AD Causal ChainKG

mechanism · 2,012 words · 5 hyp32 ana4 exp

⚙️ BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal ChainKG

mechanism · 1,896 words · 27 hyp42 ana9 exp

🧬 ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 4KG

gene · 1,799 words · 81 hyp24 ana4 exp

🧬 CSF2RA — Colony Stimulating Factor 2 Receptor Alpha ChainKG

gene · 1,774 words · 5 hyp5 ana1 exp

⚙️ PLCG2 Microglial Signaling Phagocytosis AD Causal ChainKG

mechanism · 1,757 words · 62 hyp37 ana3 exp

⚙️ ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal ChainKG

mechanism · 1,742 words · 64 hyp51 ana72 exp

🧬 FTH1 Gene — Ferritin Heavy Chain 1KG

gene · 1,699 words · 10 hyp9 ana3 exp

⚙️ SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal ChainKG

mechanism · 1,688 words · 32 hyp44 ana11 exp

⚙️ Electron Transport ChainKG

mechanism · 1,680 words · 37 hyp37 ana3 exp

🔬 Neurofilament Light Chain ProteinKG

protein · 1,671 words · 71 hyp26 ana17 exp

📊 Neurofilament Light Chain (NfL) - BiomarkerKG

biomarker · 1,666 words · 23 hyp6 ana5 exp

🧬 DYNC2H1 — Dynein Cytoplasmic 2 Heavy Chain 1KG

gene · 1,646 words · 3 hyp1 ana5 exp

⚙️ DNAJC13→Endosomal Dysfunction→PD Causal ChainKG

mechanism · 1,643 words · 12 hyp36 ana5 exp

⚙️ becn1-autophagy-initiation-neurodegeneration-causal-chainKG

mechanism · 1,584 words · 290 hyp58 ana64 exp

⚙️ PSEN1 Presenilin 1 AD Causal ChainKG

mechanism · 1,584 words · 18 hyp34 ana7 exp