biomarker 1,666 words KG: NFL 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Neurofilament Light Chain (NfL) - Biomarker

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsGFAP, TMEM119, UCHL1, UBIQUITIN, APOE, APOE4
KG Connections282 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (28)

Microbial Inflammasome Priming Prevention
Score: 0.58
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.57
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Blood-Brain Barrier SPM Shuttle System
Score: 0.56
Vagal Afferent Microbial Signal Modulation
Score: 0.52

Related Analyses (8)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85
TLR4 Activation Assay with NETs and Anti-CarP Antibodies
exploratory · proposed · Score: 0.85
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80

See Also (4)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

NFL interacts_with GFAP
NFL biomarker_for GFAP
NFL associated_with GFAP
NFL interacts_with TMEM119
NFL interacts_with UCHL1
NFL biomarker_for SYNAPTOPHYSIN
NFL interacts_with UBIQUITIN
NFL biomarker_for BACE1
NFL biomarker_for NEUROGRANIN
NFL biomarker_for TAU