🧫
Proposed experiment from debate on Synaptic pruning by microglia in early AD
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-debate-a758632b9d36
🧫 Experiment Protocol
Falsification
Metadata
| experiment_type | falsification |
| source | {'type': 'manual', 'source_name': 'debate_extraction', 'extraction_date': '2026-04-16T01:00:16.910649Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['C1Q/C1QA/C3'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | mouse |
| summary | # Proposed experiment from debate on Synaptic pruning by microglia in early AD ## Background and Rationale This study tests whether complement-mediated synaptic pruning can be therapeutically modulate |
| replication_status | conflicting |
| methodology_notes | **Phase 1: Animal Preparation and Randomization (Weeks 1-2)** • Obtain 120 APP/PS1 transgenic mice (8-10 weeks old) and 60 C1q knockout (C1qa-/-) mice crossed with APP/PS1 • Randomize into 6 groups (n |
| primary_outcome | Synaptic density quantification in hippocampal CA1 region using electron microscopy and immunofluorescence for synaptic markers, comparing decoy-treated versus vehicle-treated mice in both C1q-suffici |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from debate_extraction source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.910655'} |
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