🧫
Metabolic Pathway-Targeted Therapy in ALS
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-als-meta
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.905808Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['HK2/PLIN2/PPARGC1A'], 'diseases': ['ALS']} |
| model_system | human |
| summary | # Metabolic Pathway-Targeted Therapy in ALS ## Background and Rationale This groundbreaking clinical trial represents a precision medicine approach to ALS therapy through comprehensive metabolic pathw |
| replication_status | single_study |
| methodology_notes | **Phase 1: Patient Recruitment and Baseline Assessment (Months 1-3)** • Recruit 180 ALS patients (90 treatment, 90 placebo) meeting revised El Escorial criteria • Inclusion: Age 18-75, disease duratio |
| primary_outcome | Improvement in ALS Functional Rating Scale-Revised (ALSFRS-R) slope over 12 months in patients receiving metabolomics-guided personalized metabolic interventions compared to standard care controls. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.905814'} |
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