🧫
Axonal Transport Dysfunction Validation in Parkinson's Disease
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-axonal-t
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.896967Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['GAP43/HNRNPA2B1/MAP6'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Axonal Transport Dysfunction Validation in Parkinson's Disease ## Background and Rationale Axonal transport dysfunction represents a potentially critical upstream mechanism in Parkinson's disease (P |
| replication_status | single_study |
| methodology_notes | **Study Design and Participant Recruitment** This prospective longitudinal clinical validation study enrolls 200 Parkinson's Disease patients (100 early-stage: Hoehn-Yahr stages 1-2; 100 mid-stage: st |
| primary_outcome | Quantification of axonal transport dysfunction severity using DTI-derived metrics and CSF neurofilament levels, demonstrating significant correlation with disease progression rates over 24-month follo |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.896974'} |
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