🧫
Peroxisome Dysfunction Validation in Parkinson's Disease
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-peroxiso
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.904432Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['DGAT1/GPX4/PLIN2'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Peroxisome Dysfunction Validation in Parkinson's Disease ## Background and Rationale This clinical investigation tests the hypothesis that peroxisome dysfunction represents an upstream pathogenic dr |
| replication_status | single_study |
| methodology_notes | **Phase 1: Participant Recruitment and Baseline Assessment (Months 1-3)** • Recruit 150 PD patients (Hoehn & Yahr stages 1-3) from movement disorder clinics • Recruit 75 age-matched healthy controls • |
| primary_outcome | Significant elevation in plasma very-long-chain fatty acids (C24:0 and C26:0) and reduction in plasmalogens in PD patients compared to controls, with correlation to disease severity measured by MDS-UP |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.904439'} |
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