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Frontotemporal Dementia (FTD)

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-diseases-ftd
Related Entities
diseases-ftd
Metadata
slugdiseases-ftd
entity_typedisease
kg_node_idNone
Linked Artifacts (236)
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration90%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT90%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study90%
mentions🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M90%
mentions🧫FTD Microglia Role: Protective vs Destructive Mechanism Stud90%
mentions🧫Progranulin Replacement Therapy for FTD — Vector Development90%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration70%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT70%
related🔬TDP-43 undergoes liquid-liquid phase separation that becomes70%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration70%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT70%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study70%
related🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M70%
related🧫FTD Microglia Role: Protective vs Destructive Mechanism Stud70%
related🧫Progranulin Replacement Therapy for FTD — Vector Development70%
mentions🧪Arginine Methylation Enhancement Therapy65%
mentions🧪TREM2-Mediated Selective Aggregate Clearance Pathway65%
mentions🧪PARP1 Inhibition Therapy65%
mentions🧪Glycine-Rich Domain Competitive Inhibition65%
mentions🧪R-Loop Resolution Enhancement Therapy65%
mentions🧪Serine/Arginine-Rich Protein Kinase Modulation65%
mentions🧪Nucleolar Stress Response Normalization65%
mentions🧪Cross-Seeding Prevention Strategy65%
mentions🧪Trans-Synaptic Adhesion Molecule Modulation65%
mentions🧪RNA Granule Nucleation Site Modulation65%
mentions🔬What are the mechanisms underlying tdp-43 phase separation t60%
mentions🔬What are the mechanisms underlying rna binding protein dysre60%
mentions🔬RNA binding protein dysregulation across ALS FTD AD60%
mentions🔬TDP-43 undergoes liquid-liquid phase separation that becomes60%
mentions🔬RNA binding protein dysregulation across ALS FTD and AD60%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study60%
mentions🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M60%
mentions🧫FTD Microglia Role: Protective vs Destructive Mechanism Stud60%
mentions🧫Progranulin Replacement Therapy for FTD — Vector Development60%
mentions🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD60%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS60%
see_also📖Packard Center for ALS Research60%
see_also📖entities-fus60%
see_also📖ABCD3 Gene60%
see_also📖ACTB Gene60%
see_also📖CHMP2A60%
see_also📖FUNDC1 — FUN14 Domain Containing 160%
see_also📖G3BP160%
see_also📖stathmin60%
see_also📖Apoptosis Pathway in Neurodegeneration60%
see_also📖stathmin60%
see_also📖Stathmin-1 Protein60%
see_also📖Stathmin-2 Protein60%
see_also📖Stathmin-2** is a protein. This page describes its structure60%
see_also📖DTI White Matter Changes in CBS/PSP60%
see_also📖Sleep Biomarkers for CBS and PSP60%
see_also📖Locus Coeruleus Noradrenergic in Progressive Supranuclear Pa60%
see_also📖Nigral Microglia in Progressive Supranuclear Palsy60%
see_also📖Pedunculopontine Nucleus Cholinergic in Progressive Supranuc60%
see_also📖Red Nucleus Psp60%
see_also📖Subthalamic Nucleus Neurons in Progressive Supranuclear Pals60%
see_also📖AMX0035 for Progressive Supranuclear Palsy60%
see_also📖BIIB080 (MAPTRx) ASO Therapy for PSP60%
see_also📖Davunetide (AL-108) PSP Trial60%
see_also📖First-in-Human 4R Tau Ligand Study in PSP60%
see_also📖FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear 60%
see_also📖Gosuranemab (BIIB092) PSP Trial60%
see_also📖gv1001-psp60%
see_also📖Lithium Carbonate PSP Trial60%
see_also📖LY-3372689 LOTUS Trial - Phase 2 in Progressive Supranuclear60%
see_also📖NADAPT Study: NAD Replenishment Therapy for Atypical Parkins60%
see_also📖nct02605785-tau-pet-psp60%
see_also📖neflamapimod-psp60%
see_also📖NIO752 Tau ASO PSP Trial60%
see_also📖Syde® Digital Endpoints for PSP (NCT07389018)60%
see_also📖tetrabenazine-psp60%
see_also📖Tilavonemab PSP Trial Failure Analysis60%
see_also📖TPN-101 for Progressive Supranuclear Palsy60%
see_also📖Typhaneoside for Progressive Supranuclear Palsy60%
see_also📖UCB0107 for Progressive Supranuclear Palsy60%
see_also📖Eye Tracking and Saccade Testing in Progressive Supranuclear60%
see_also📖Metabolic Imaging and PET Tracers in CBS/PSP60%
see_also📖Neuropsychological Testing in CBS and PSP60%
see_also📖Polysomnography and Sleep Study Testing for Atypical Parkins60%
see_also📖Salivary Biomarkers in Corticobasal Syndrome60%
see_also📖transcranial-sonography-cbs-psp60%
see_also📖Whole Genome Sequencing for CBS/PSP60%
see_also📖Progressive Supranuclear Palsy (PSP)60%
see_also📖PSP Rating Scale (PSPRS)60%
see_also📖Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri60%
see_also📖Brainstem Circuit Modulation for PSP60%
see_also📖c9orf72-als-ftd-phenotype-mechanism60%
see_also📖CRISPR Gene Correction Approaches for CBS/PSP60%
see_also📖N-of-1 Clinical Trial Design for CBS/PSP60%
see_also📖PSP Gene - Persephin60%
see_also📖Personalized Antisense Oligonucleotide (ASO) Therapy60%
see_also📖Axonal Transport Dysfunction in Progressive Supranuclear Pal60%
see_also📖Computational Models of Tau Propagation in Progressive Supra60%
see_also📖Computational Tau Spreading Models in Progressive Supranucle60%
see_also📖Exosome-Mediated Tau Propagation in Progressive Supranuclear60%
see_also📖Heat Shock Protein Dysfunction in Progressive Supranuclear P60%
see_also📖integrin-ecm-signaling-cbs-psp60%
see_also📖lipid-metabolism-psp60%
see_also📖Lysosomal Dysfunction in Neurodegeneration60%
see_also📖Metabolomic Alterations in Progressive Supranuclear Palsy60%
see_also📖Neurotransmitter Dysfunction in Progressive Supranuclear Pal60%
see_also📖Oligodendroglial Involvement in Progressive Supranuclear Pal60%
see_also📖Ribosomal and Translation Dysfunction in Progressive Supranu60%
see_also📖Selective Neuronal Vulnerability in Progressive Supranuclear60%
see_also📖Vascular and Endothelial Dysfunction in Progressive Supranuc60%
see_also📖PSP Australia60%
see_also📖PSP Canada60%
see_also📖PSP France60%
see_also📖PSP Germany60%
see_also📖PSP Italy — Associazione Italiana PSP60%
see_also📖PSP Japan — 日本PSP協会60%
see_also📖PSP Netherlands — PSP Vereniging Nederland60%
see_also📖PSP Scandinavia60%
see_also📖PSP Spain — Asociación Española de PSP60%
see_also📖PSP Association UK60%
see_also📖cognitive-reserve-cbs-psp60%
see_also📖combination-therapy-cbs-psp60%
see_also📖Hormone Neuroprotection in CBS/PSP60%
see_also📖pharmacogenomics-cbs-psp60%
see_also📖protective-strategies-cbs-psp60%
see_also📖section-155-art-therapy-creative-arts-therapies-cbs-psp60%
see_also📖section-181-advanced-music-rhythm-therapy-cbs-psp60%
see_also📖section-186-crispr-base-editing-therapeutics-cbs-psp60%
see_also📖section-197-advanced-clinical-trial-design-cbs-psp60%
see_also📖section-198-advanced-precision-medicine-implementation-cbs-p60%
see_also📖section-209-glp-1-receptor-agonists-cbs-psp60%
see_also📖section-228-advanced-dance-movement-therapy-cbs-psp60%
see_also📖section-239-advanced-light-therapy-photobiomodulation-cbs-ps60%
see_also📖section-242-advanced-stem-cell-therapy-neuronal-replacement-60%
see_also📖GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease B60%
see_also📖DNA Damage Repair Deficiency Validation Study in Parkinson&#60%
see_also📖DYSF — Dysferlin60%
see_also📖FAM134B — Family With Sequence Similarity 134 Member B60%
see_also📖fip20060%
see_also📖FMR1 — Fragile X Messenger Ribonucleoprotein 160%
see_also📖trim260%
see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
see_also📖Hepsin Protein60%
related🧪Arginine Methylation Enhancement Therapy58%
related🧪TREM2-Mediated Selective Aggregate Clearance Pathway58%
related🧪PARP1 Inhibition Therapy58%
related🧪Glycine-Rich Domain Competitive Inhibition58%
related🧪R-Loop Resolution Enhancement Therapy58%
related🧪Serine/Arginine-Rich Protein Kinase Modulation58%
related🧪Nucleolar Stress Response Normalization58%
related🧪Cross-Seeding Prevention Strategy58%
related🧪Trans-Synaptic Adhesion Molecule Modulation58%
related🧪RNA Granule Nucleation Site Modulation58%
related🔬What are the mechanisms underlying tdp-43 phase separation t54%
related🔬What are the mechanisms underlying rna binding protein dysre54%
related🔬RNA binding protein dysregulation across ALS FTD AD54%
related🔬TDP-43 undergoes liquid-liquid phase separation that becomes54%
related🔬RNA binding protein dysregulation across ALS FTD and AD54%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study54%
related🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M54%
related🧫FTD Microglia Role: Protective vs Destructive Mechanism Stud54%
related🧫Progranulin Replacement Therapy for FTD — Vector Development54%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration50%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT50%
mentions🧫FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation50%
mentions🧫Microtubule domain analysis in adult axons50%
mentions🧫Tau depletion effects on neuronal development in primary cul50%
mentions🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers50%
mentions🧪Cryptic Exon Silencing Restoration50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪Lysosomal Membrane Repair Enhancement50%
mentions🧪DNMT1-Targeting Antisense Oligonucleotide Reset50%
mentions🧪Stress Granule Phase Separation Modulators50%
mentions🧪Phase-Separated Organelle Targeting50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪Mitochondrial Transfer Pathway Enhancement50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro50%
mentions🧪APOE Isoform Conversion Therapy50%
mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%
mentions🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
related🧪Mitochondrial-Lysosomal Contact Site Engineering50%
related🧪Lysosomal Calcium Channel Modulation Therapy50%
related🧪Lysosomal Enzyme Trafficking Correction50%
related🧪Blood-Brain Barrier SPM Shuttle System50%
related🧪Lysosomal Positioning Dynamics Modulation50%
related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%
related🧪Extracellular Vesicle Biogenesis Modulation50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr44%
mentions🧫ALS Regional Onset and Spread: Network-Level Staging Model44%
mentions🧫Environmental Exposure Causal Attribution in ALS — Experimen44%
mentions📖Adam L. Boxer40%
mentions📖Alnylam Pharmaceuticals40%
mentions📖Bruce L. Miller40%
mentions📖Charité – Universitätsmedizin Berlin40%
mentions📖Companies Dashboard40%
mentions📖James Rowe40%
mentions📖John R. Hodges40%
mentions📖John Ravits40%
mentions📖King's College London40%
mentions📖Leonard Petrucelli40%
mentions📖NeuroWiki Progress40%
mentions📖Olink Proteomics40%
mentions📖Pinteon40%
mentions📖QurAlis Corporation40%
mentions📖QurAlis40%
mentions📖Researchers Dashboard40%
mentions📖University of Chicago40%
mentions📖University of North Carolina at Chapel Hill40%
mentions📖University of Rostock40%
mentions📖dzne40%
mentions📖yale-university40%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
mentions🔬What are the mechanisms underlying protein aggregation cross40%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,40%
related🧪Cryptic Exon Silencing Restoration40%
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