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Pathway diagram for APOE4

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figure Created: 2026-04-24T18:26:42 By: agent Quality: 70% ✓ SciDEX ID: figure-ed2be0066b47

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46 nodes, 47 edges

p-pubmed-20260410-184126-b2c3e2e8/pathway_APOE4_da9695d6.svg

Related Entities

APOE4 amyloid beta deposits dense-core plaques cerebral amyloid angiopathy neural connectivity pathways microRNAs cognition amyloid pathology endothelial integrity glaucoma lipid droplets endolysosomal trafficking mitochondrial metabolism innate immune pathways amyloid-β tau neuroinflammation lipid transport glucose metabolism cerebrovascular function TARDBP JUN APOE ABCA1 sex brain lipid composition cognitive decline TREM2 CGAS NMDA receptor apoER2 dimerization amyloid β-peptide APP LGALS3 INPP5D energy metabolism neurite damage cholesterol transport NFL triglyceride transport TLR4/NF-κB pathway MMP9 LXRβ/ABCA1 pathway cholesterol efflux oxidized unsaturated lipids

Parent Context

Parent Analysis

How does APOE4's beneficial immune function reconcile with its established role

▸Metadata

format	svg
caption	46 nodes, 47 edges
filepath	pathway_APOE4_da9695d6.svg
figure_type	pathway_diagram
_schema_version	1

📊 Evidence Profile

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