protein

NMDA RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDA RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

2Analyses

46Outgoing

50Incoming

0Experiments

9Debates

Summary

Page for NMDA Receptor Protein

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🔬 Protein Info

Gene Symbol	NMDA RECEPTOR
Molecular Weight	220 kDa
Pathways	Neurodegeneration
Associated Diseases	Alzheimer
Interactions	AMPA RECEPTOR, NMDA
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    NMDA_RECEPTOR["NMDA RECEPTOR"]
    NMDA_RECEPTOR -->|"involved_in"| Neurodegeneration["Neurodegeneration"]
    NMDA_RECEPTOR -->|"mediates"| Synaptic_Plasticity["Synaptic Plasticity"]
    NMDA_RECEPTOR -->|"modulates"| ARHGEF7["ARHGEF7"]
    NMDA_RECEPTOR -->|"activates"| Als["Als"]
    NMDA_RECEPTOR -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    Memantine["Memantine"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_A["Compound A"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_B["Compound B"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_C["Compound C"] -->|"inhibits"| NMDA_RECEPTOR
    RAC1["RAC1"] -->|"regulates"| NMDA_RECEPTOR
    SYNAPSE["SYNAPSE"] -->|"regulates"| NMDA_RECEPTOR
    ARHGEF7 -->|"regulates"| NMDA_RECEPTOR
    P53["P53"] -->|"inhibits"| NMDA_RECEPTOR

Outgoing (46)

Target	Relation	Type	Str
Ischemic Stroke	contributes_to	disease	0.90
hippocampus	expressed_in	brain_region	0.90
glutamate signaling	activates	pathway	0.90
synaptic plasticity	activates	pathway	0.90
neurons	expressed_in	cell_type	0.90
unfolded protein response	activates	pathway	0.80
cortex	expressed_in	brain_region	0.80
ferroptosis	regulates	pathway	0.70
astrocytes	expressed_in	cell_type	0.70
Depression	regulates	disease	0.60
Alzheimer	inhibits	disease	0.60
Als	activates	disease	0.60
neuropeptide Y	binds	neurotransmitter	0.60
glycine	binds	neurotransmitter	0.60
Als	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Huntington	regulates	disease	0.60
Anxiety	activates	disease	0.60
pyroptosis	activates	pathway	0.60
hypothalamus	expressed_in	brain_region	0.60
thalamus	expressed_in	brain_region	0.60
Epilepsy	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Anxiety	inhibits	disease	0.60
Schizophrenia	inhibits	disease	0.60
Neuroinflammation	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Alzheimer	activates	disease	0.60
Aging	activates	disease	0.60
blood-brain barrier	expressed_in	brain_region	0.60
GABAergic neurons	expressed_in	cell_type	0.60
B cells	expressed_in	cell_type	0.60
nucleus accumbens	expressed_in	brain_region	0.60
Multiple Sclerosis	activates	disease	0.60
Als	regulates	disease	0.60
neural stem cells	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
Pi3K/Akt	activates	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Oxidative Stress	inhibits	pathway	0.55
Synaptic Plasticity	inhibits	pathway	0.55
Glycolysis	activates	pathway	0.55
Calcium Signaling	associated_with	pathway	0.55
GLUTAMATE	activates	concept	0.50
Synaptic Plasticity	regulates	pathway	0.50
GLUTAMATE	associated_with	concept	0.50

Incoming (131)

Source	Relation	Type	Str
GW201	modulates	compound	0.95
Mk-801	inhibits	drug	0.95
Apoer2	activates	receptor	0.90
neurodegeneration	involves	disease	0.90
APOE	modulates	gene	0.90
MTNR1B	associated_with	gene	0.90
MTNR1A	expressed_in	gene	0.90
MTNR1A	associated_with	gene	0.90
depression	involves	disease	0.90
MTNR1A	regulates	gene	0.90
Fibrillar Amyloid Beta	activates	compound	0.85
REELIN	activates	protein	0.85
RLN	activates	gene	0.85
amyloid beta oligomers	inhibits	compound	0.80
memantine	inhibits	compound	0.80
MTNR1A	interacts_with	gene	0.80
schizophrenia	involves	disease	0.80
epilepsy	involves	disease	0.70
APOE4	enhances	gene	0.70
GABA	expressed_in	gene	0.70
Fyn	regulates	protein	0.70
MTNR1A	protects_against	gene	0.70
MTNR1A	treats	gene	0.70
APP	regulates	gene	0.70
MTNR1A	activates	gene	0.70
anxiety	involves	disease	0.70
Alzheimer's disease	involves	disease	0.70
BDNF	expressed_in	gene	0.70
stroke	involves	disease	0.70
NLRP3	activates	gene	0.70
BDNF	activates	gene	0.70
NLRP3	implicated_in	gene	0.60
BDNF	regulates	gene	0.60
TLR2	activates	gene	0.60
TLR4	activates	gene	0.60
TLR2	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
AKT1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
IL6	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
memantine	secreted_by	compound	0.60
SNCA	regulates	gene	0.60
SOD1	regulates	gene	0.60
NFE2L2	regulates	gene	0.60
SNCA	upstream_of	gene	0.60
SOD1	upstream_of	gene	0.60
NFE2L2	upstream_of	gene	0.60