🧫
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neurons Degenerate
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-selectiv
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.898481Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['GAP43/MIRO1/PRKAA1'], 'diseases': ['Neurodegeneration']} |
| model_system | human |
| summary | # Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neurons Degenerate ## Background and Rationale The phenomenon of selective neuronal vulnerability to aging represents one of the most |
| replication_status | single_study |
| methodology_notes | 1. **Human Brain Sample Collection**: Obtain post-mortem brain tissue from neurologically normal individuals across age groups (n=60): young adults (20-35 years, n=20), middle-aged (45-65 years, n=20) |
| primary_outcome | Validate Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neurons Degenerate |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.898486'} |
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