🧫
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-cbs-psp-
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.901334Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['CBS'], 'diseases': ['Neurodegeneration']} |
| model_system | cell_line |
| summary | # CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study ## Background and Rationale Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) represent distinct clinical phen |
| replication_status | single_study |
| methodology_notes | Phase 1 (Months 1-3): Tissue procurement and processing. Obtain fresh-frozen post-mortem brain tissue from CBS (n=15), PSP (n=15), and age-matched controls (n=15) within 12-hour post-mortem interval. |
| primary_outcome | Cell-type-specific signatures distinguishing CBS from PSP in single-nucleus multi-omics |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.901341'} |
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