🧫
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have Not Succeeded
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-anti-tau
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.903578Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['PSP'], 'diseases': ['ALS']} |
| model_system | human |
| summary | # Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have Not Succeeded ## Background and Rationale This experiment addresses a critical therapeutic failure in neurodegeneration: why anti |
| replication_status | conflicting |
| methodology_notes | **Phase 1: Patient Cohort Assembly and Characterization (Months 1-6)** • Recruit 200 PSP patients from completed anti-tau trials (gosuranemab, tilavonemab) and 100 treatment-naive PSP patients • Colle |
| primary_outcome | Validate Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have Not Succeeded |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.903584'} |
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