Trans-Synaptic Adhesion Molecule Modulation

**Molecular Mechanism and Rationale** The neurexin-neuroligin trans-synaptic adhesion system represents a critical molecular bridge that maintains synaptic integrity while potentially facilitating pathological tau propagation in neurodegenerative diseases. Neuroligin-1 (NLGN1), the primary target of this therapeutic approach, is a postsynaptic cell adhesion molecule that forms heterotypic interactions with presynaptic neurexins (NRXN1, NRXN2, NRXN3). This interaction occurs through the extracel...