gene 1,622 words KG: ABCA2 2026-03-27
kind:genesection:genesstate:published
Contents

ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2

🧬 Gene Info
Gene SymbolABCA2
AliasesPage for ABCA2 Gene
Chromosome9q34.3 (human)
Protein FamilyABC transporter family, subfamily A
Protein TypeTransporter
Functionencodes a member of the ATP-binding cassette transporter family, predominantly expressed in the brain.
Molecular Weight~270 kDa
Amino Acids2436 aa
PathwaysCholesterol
UniProt IDQ9BZC7
NCBI Gene ID20
GeneCardsABCA2
Human Protein AtlasABCA2
ProteinATP-binding cassette subfamily A member 2
SynonymsABC2, KIAA0882
Associated DiseasesAlzheimer's disease risk, Neurodegeneration
InteractionsLDLR, APOC3, APOA1, APOC1, APOC2, APOE
KG Connections100 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

ABCA2 expressed_in ATP7A
ABCA2 expressed_in ABCG1
ABCA2 expressed_in SLC22A5
ABCA2 expressed_in ABCG2
ABCA2 regulates PSEN2
ABCA2 regulates TAU
ABCA2 activates LDLR
ABCA2 activates APOC3
ABCA2 transports PSEN1
ABCA2 transports TAU