gene 1,622 words KG: ABCA2
Contents

ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2

🧬 Gene Info
Gene SymbolABCA2
AliasesPage for ABCA2 Gene
Chromosome9q34.3 (human)
Protein FamilyABC transporter family, subfamily A
Protein TypeTransporter
Functionencodes a member of the ATP-binding cassette transporter family, predominantly expressed in the brain.
Molecular Weight270 kDa
Amino Acids2436 aa
PathwaysCholesterol
UniProt IDQ9BZC7
NCBI Gene ID20
GeneCardsABCA2
Human Protein AtlasABCA2
Associated DiseasesAlzheimer's disease risk, Neurodegeneration
InteractionsABCA1, APOA1, APOC1, APOC2, APOC3, APOD
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

ABCA2 expressed_in ABCG2
ABCD3 expressed_in ABCA2
ABCA2 expressed_in ATP7A
ABCA2 expressed_in ABCG1
ABCA2 expressed_in SLC22A5
LRP8 activates ABCA2
APOA1 activates ABCA2
MAPT regulates ABCA2
LRP1 activates ABCA2
LIPA regulates ABCA2

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