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CYP46A1 — Cholesterol 24-Hydroxylase

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-cyp46a1
Related Entities
CYP46A1
Metadata
sluggenes-cyp46a1
entity_typegene
kg_node_idCYP46A1
Linked Artifacts (176)
mentions🧪CYP46A1 Overexpression Gene Therapy90%
targets🧪CYP46A1 Overexpression Gene Therapy90%
analysis_target🔬Investigate how lipid raft composition (cholesterol metaboli80%
mentions🧪CYP46A1 Overexpression Gene Therapy80%
related🧪CYP46A1 Overexpression Gene Therapy80%
related🧪CYP46A1 Overexpression Gene Therapy80%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli70%
mentions🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%
mentions🧫Wilson Disease Neurodegeneration: Mechanism and Therapeutic 70%
mentions🧪APOE Isoform Conversion Therapy70%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%
mentions🧪APOE Isoform Expression Across Glial Subtypes70%
related🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration70%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas70%
related🔬Investigate how lipid raft composition (cholesterol metaboli70%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
see_also🧪CYP46A1 Overexpression Gene Therapy70%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli63%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise63%
related🧫Wilson Disease Neurodegeneration: Mechanism and Therapeutic 63%
related🧪APOE Isoform Conversion Therapy63%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%
related🧪APOE Isoform Expression Across Glial Subtypes63%
see_also📖PSD-95 (Postsynaptic Density Protein 95)60%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
see_also📖ABCA2 Gene - ATP Binding Cassette Subfamily A Member 260%
see_also📖APOC1 Gene — Apolipoprotein C-I60%
see_also📖LRP8 Gene60%
see_also📖Alzheimer Indonesia60%
see_also📖Cognition Therapeutics60%
see_also📖Packard Center for ALS Research60%
see_also📖LIPA Gene60%
see_also📖Brain Connectivity-Targeted tACS Trial in Early AD60%
see_also📖brain-regions60%
see_also📖Brain Region Connectivity Index60%
see_also📖Brain Region Disease Involvement60%
see_also📖Brain Region Vulnerability Map60%
see_also📖Brain Endothelial Cells60%
see_also📖Brain Organoid Neurons60%
see_also📖Brain Pericytes in Neurodegeneration60%
see_also📖Brain Pericytes in Neurodegeneration60%
see_also📖Brain Vascular Endothelial Cells60%
see_also📖Brain Capillary Endothelial Cells60%
see_also📖Brain Endothelial Cells60%
see_also📖Brain Endothelial Cells in Neurodegeneration60%
see_also📖Brain Ependymal Cells60%
see_also📖Brain Pericytes60%
see_also📖Brain Pericytes in Neurodegeneration60%
see_also📖Brain Venous Endothelial Cells60%
see_also📖Brain Activity During Complex Walking in Atypical Parkinsoni60%
see_also📖Brain Health Roundtable and AADAPT Act60%
see_also📖Brain Insulin Signaling60%
see_also📖Brain Health Roundtable and AADAPT Act: 2026 Dementia Care P60%
see_also📖Brain Connectivity-Targeted tACS Trial in Early AD60%
see_also📖npc160%
see_also📖Brain Hyperconnectivity-Tau Spread Hypothesis in Alzheimer&#60%
see_also📖Brain & Behavior Research Foundation60%
see_also📖Brain-Computer Interface Investment Landscape60%
see_also📖Brain Region Vulnerability in 4R-Tauopathies60%
see_also📖brain-age-gap-amyloid-ad60%
see_also📖Brain Endothelial Cell Dysfunction in Neurodegeneration60%
see_also📖Brain Insulin Signaling Pathway60%
see_also📖Brain Region Therapeutic Targeting Index60%
see_also📖Brain Reserve in Neurodegeneration60%
see_also📖Brain Volume Changes in Early Alzheimer's Disease60%
see_also📖Brain-Computer Interface Technologies60%
see_also📖Brain-Computer Interface for Amyotrophic Lateral Sclerosis60%
see_also📖Brain-Computer Interface for Corticobasal Degeneration60%
see_also📖Brain-Computer Interface for Frontotemporal Dementia60%
see_also📖Brain-Computer Interface for Huntington's Disease60%
see_also📖Brain-Computer Interface Technologies60%
see_also📖Brain-Computer Interface for Lewy Body Dementia60%
see_also📖Brain-Computer Interface for Multiple System Atrophy60%
see_also📖Brain-Computer Interface for Normal Pressure Hydrocephalus60%
see_also📖Brain-Computer Interface for Parkinson's Disease60%
see_also📖Brain-Computer Interface for Progressive Supranuclear Palsy60%
see_also📖Brain-Computer Interface Technology Landscape60%
see_also📖Brain-Computer Interface for Vascular Dementia60%
see_also📖brain-computer-interface60%
see_also📖Brain-Computer Interfaces60%
see_also📖Brain Knowledge Platform60%
see_also📖Brain Organoid-Silicon Interface Technology60%
see_also📖Brain Organoids60%
see_also📖Brain Organoids for Neurodegeneration Research60%
see_also📖Brain Shuttle Technologies: BBB Delivery Platforms60%
see_also📖Brain Shuttle Technologies60%
see_also📖Brain-to-Brain Interface Technology60%
see_also📖Brain Waste Clearance and CSF Dynamics Therapies60%
see_also📖Brain-Computer Interface Therapy for Neurodegeneration60%
see_also📖Brain Drug Delivery Challenges Overview60%
see_also📖CYP7B1 Gene - Hereditary Spastic Paraplegia 560%
see_also📖spermidine-neurodegeneration60%
see_also📖Memory Prosthetic BCI for Alzheimer's Disease60%
see_also📖CYP27A1 Gene60%
mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
mentions🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho50%
mentions🧪SASP-Mediated Complement Cascade Amplification50%
mentions🧪Transcriptional Autophagy-Lysosome Coupling50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Gamma entrainment therapy to restore hippocampal-cortical sy50%
mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%
mentions🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise50%
mentions🧫Wilson Disease Neurodegeneration: Mechanism and Therapeutic 50%
mentions🧪Membrane Cholesterol Gradient Modulators50%
mentions🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Gamma entrainment therapy to restore hippocampal-cortical sy50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor50%
mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration50%
mentions🧪Membrane Cholesterol Gradient Modulators50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🧪APOE Isoform Conversion Therapy50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE50%
see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 50%
see_also📖ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT0739250%
see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh45%
see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and45%
see_also📖NCT07477431 - Levetiracetam for Persons at Risk for Alzheime45%
see_also📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di45%
see_also📖nct0550878945%
see_also📖remternetug-anti-amyloid-alzheimers45%
see_also📖UPenn Observational Research Repository (NCT04715399)45%
see_also📖APOE2 (Apolipoprotein E2)45%
see_also📖APOE3 (Apolipoprotein E3)45%
see_also📖APOE4 (Apolipoprotein E4)45%
see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread45%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Ganglioside Rebalancing Therapy40%
related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors40%
related🧪Flotillin-1 Stabilization Compounds40%
related🧪Selective Acid Sphingomyelinase Modulation Therapy40%
related🧪Sphingomyelin Synthase Activators for Raft Remodeling40%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia40%
related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation40%
related🧪Complement C1QA Spatial Gradient in Cortical Layers40%
related🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation40%
related🧪APOE Isoform Expression Across Glial Subtypes40%
related🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho40%
related🧪SASP-Mediated Complement Cascade Amplification40%
related🧪Membrane Cholesterol Gradient Modulators40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy40%
related🧪Membrane Cholesterol Gradient Modulators40%
related🧪Sphingomyelin Synthase Activators for Raft Remodeling40%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di35%
mentions🔬Investigate prion-like spreading of tau pathology through co35%
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