🧫
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-synaptic
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.902317Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['ATP'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease ## Background and Rationale Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the |
| replication_status | single_study |
| methodology_notes | Phase 1 (Weeks 1-4): Stereotaxic injection of AAV9-PGC1alpha or AAV9-GFP control vectors (1x10^12 vg/ml, 2μl) into substantia nigra of 8-week-old male C57BL/6 mice (n=30/group). Coordinates: AP -3.1mm |
| primary_outcome | Preservation of TH+ striatal fiber density with PGC-1alpha overexpression vs. controls |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.902323'} |
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