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HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-hmgcr
Related Entities
HMGCR
Metadata
sluggenes-hmgcr
entity_typegene
kg_node_idHMGCR
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (115)
mentions🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration90%
mentions🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis90%
related🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration90%
related🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis90%
mentions🧪APOE Isoform Conversion Therapy70%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%
related🧫Cytochrome Therapeutics70%
related🧫Cytochrome Therapeutics70%
see_also🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration70%
mentions🧪CYP46A1 Overexpression Gene Therapy65%
related🧪APOE Isoform Conversion Therapy63%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
see_also📖nrp160%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
see_also📖ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member 160%
see_also📖ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 260%
see_also📖ADRA2A Gene60%
see_also📖ADRB2 Gene60%
see_also📖CHD4 Gene60%
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see_also📖KCNK5 Gene60%
see_also📖NLGN2 Gene60%
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see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%
see_also📖PITX3 Gene60%
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see_also📖TUBB1 — Tubulin Beta 160%
see_also📖Lysosomal Dysfunction in Neurodegeneration60%
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see_also📖a2m60%
see_also📖igf2bp360%
see_also📖ALDH2 — Aldehyde Dehydrogenase 260%
see_also📖DLX5 Gene60%
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related🧪CYP46A1 Overexpression Gene Therapy58%
related🧪Noradrenergic-Tau Propagation Blockade55%
related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th55%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
mentions🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
mentions🧪Flotillin-1 Stabilization Compounds50%
mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%
mentions🧪Glial Glycocalyx Remodeling Therapy50%
mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%
mentions🧪Vagal Afferent Microbial Signal Modulation50%
mentions🧪Flotillin-1 Stabilization Compounds50%
mentions🧪Noradrenergic-Tau Propagation Blockade50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%
mentions🧪Biorhythmic Interference via Controlled Sleep Oscillations50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪Pericyte Contractility Reset via Selective PDGFR-β Agonism50%
mentions🧪Prefrontal sensory gating circuit restoration via PV interne50%
mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%
mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🧪APOE Isoform Conversion Therapy50%
related🧪CYP46A1 Overexpression Gene Therapy50%
related🧪Membrane Cholesterol Gradient Modulators50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
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see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE50%
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see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh45%
see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and45%
see_also📖A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month45%
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mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Epigenetic Memory Reprogramming for Alzheimer's Disease40%
related🧪Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar40%
related🧪Context-Dependent CRISPR Activation in Specific Neuronal Sub40%
related🧪Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci40%
related🧪Programmable Neuronal Circuit Repair via Epigenetic CRISPR40%
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related🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli40%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK40%
related🧪Flotillin-1 Stabilization Compounds40%
related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th40%
related🧪Glial Glycocalyx Remodeling Therapy40%
related🧪Vagal Afferent Microbial Signal Modulation40%
related🧪Context-Dependent CRISPR Activation in Specific Neuronal Sub40%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc40%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc40%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di40%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di40%
mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp35%
mentions🔬What are the mechanisms underlying neuroinflammation resolut35%
mentions🔬What are the mechanisms underlying what are the mechanisms b35%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
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