Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits

**Background and Rationale** Neurodegeneration is fundamentally linked to metabolic dysfunction, with aging neurons displaying impaired energy homeostasis, mitochondrial dysfunction, and reduced cellular resilience. The metabolic decline observed in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis involves compromised oxidative phosphorylation, dysregulated glucose metabolism, and accumulated oxidative damage. Traditional therapeut...