Context-Dependent CRISPR Activation in Specific Neuronal Subtypes

**Background and Rationale** Neurodegeneration encompasses a diverse array of disorders characterized by progressive loss of specific neuronal populations, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). A fundamental challenge in developing effective therapeutics is the cellular heterogeneity of the central nervous system, where different neuronal subtypes exhibit distinct vulnerabilities and responses to pathological insults. ...