gene 2,569 words KG: SPI1 2026-03-25
kind:genesection:genesstate:published
Contents

SPI1 Gene - PU.1

🧬 Gene Info
Gene SymbolSPI1
Full NamePU.1 Transcription Factor / Spi-1 Proto-Oncogene
AliasesSPI1/PU.1
Chromosome19q13.3
Protein TypeTranscription Factor
Functionencodes a transcription factor of the E26 transformation-specific (ETS) family.
Amino Acids270 aa
PathwaysAmyloid, Mtor, Pi3K/Akt
UniProt IDP17947
NCBI Gene ID6678
Ensembl IDENSG00000135336
OMIM165010
GeneCardsSPI1
Human Protein AtlasSPI1
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer's disease
InteractionsTAU, HNF4A, AXIN1, TBP, YWHAZ, SOCS3
KG Connections439 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (7)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (5)

scRNA-seq analysis of human atherosclerotic plaques
exploratory · proposed · Score: 0.90
Gene expression validation in apoE-/- mice
validation · proposed · Score: 0.85
ox-LDL treatment of RAW264.7 macrophages
exploratory · proposed · Score: 0.85
Validation of hub genes in ox-LDL treated RAW264.7 macrophag
exploratory · proposed · Score: 0.80
Validation of hub genes in apoE-/- atherosclerotic mice
validation · proposed · Score: 0.80

See Also (6)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SPI1 associated_with APOE
SPI1 expressed_in C1QA
SPI1 expressed_in C1QC
SPI1 expressed_in C1Q
SPI1 associated_with GBM
SPI1 regulates CEBPA
SPI1 regulates TP53
SPI1 regulates TFE3
SPI1 biomarker_for STXBP2
SPI1 biomarker_for FLNA