gene 2,569 words KG: SPI1
Contents

SPI1 Gene - PU.1

🧬 Gene Info
Gene SymbolSPI1
Full NamePU.1 Transcription Factor / Spi-1 Proto-Oncogene
AliasesSPI1/PU.1
Chromosome19q13.3
Protein TypeTranscription Factor
Functionencodes a transcription factor of the E26 transformation-specific (ETS) family.
Amino Acids270 aa
PathwaysAmyloid, Mtor, Pi3K/Akt
UniProt IDP17947
NCBI Gene ID6678
Ensembl IDENSG00000135336
OMIM165010
GeneCardsSPI1
Human Protein AtlasSPI1
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsActin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX HypothesesSPI1-C1Q Transcriptional Circuit Drives Cerebrovas
Neurovascular Unit SPI1 Signaling Hub
Epigenetic SPI1 Reprogramming Therapy (+3 more)
KG Connections434 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.89
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
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Related Analyses (7)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (5)

scRNA-seq analysis of human atherosclerotic plaques
exploratory · proposed · Score: 0.90
Gene expression validation in apoE-/- mice
validation · proposed · Score: 0.85
ox-LDL treatment of RAW264.7 macrophages
exploratory · proposed · Score: 0.85
Validation of hub genes in ox-LDL treated RAW264.7 macrophag
exploratory · proposed · Score: 0.80
Validation of hub genes in apoE-/- atherosclerotic mice
validation · proposed · Score: 0.80

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

GBM associated_with SPI1
C1Q expressed_in SPI1
C1QA expressed_in SPI1
C1QC expressed_in SPI1
SPI1 associated_with APOE
CEBPA regulates SPI1
HSPA1A therapeutic_target SPI1
TFE3 regulates SPI1
TP53 regulates SPI1
SPI1 expressed_in C1QA

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