Microglial Efferocytosis Enhancement via GPR32 Superagonists

**Molecular Mechanism and Rationale** The G-protein coupled receptor 32 (GPR32), encoded by the CMKLR1 gene, serves as the primary receptor for resolvin D1 (RvD1), a specialized pro-resolving mediator (SPM) derived from docosahexaenoic acid. In the context of neurodegeneration, GPR32 represents a critical molecular switch that governs microglial transition from inflammatory to resolution phenotypes. Under physiological conditions, RvD1 binding to GPR32 initiates a cascade involving Gα(i/o) prot...