Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AD RISK LOCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AD RISK LOCI |
| Key Genes/Proteins | ALZHEIMER'S DISEASE, CTSH, PILRB, GBA, CR1, ALZHEIMER |
| Related Diseases | Alzheimer, Dementia, Ms, ALS |
Knowledge base pages for this entity
graph TD
AD_RISK_LOCI["AD RISK LOCI"]
AD_RISK_LOCI ---|"associated"| microglial_enhancers["microglial enhancers"]
AD_RISK_LOCI ---|"associated"| Alzheimer["Alzheimer"]
AD_RISK_LOCI ---|"associated"| Dementia["Dementia"]
AD_RISK_LOCI ---|"associated"| Ms["Ms"]
AD_RISK_LOCI ---|"associated"| ALS["ALS"]
CR2["CR2"] ---|"associated"| AD_RISK_LOCI
GENETIC_RISK_LOCI["GENETIC RISK LOCI"] ---|"associated"| AD_RISK_LOCI
TREM2["TREM2"] ---|"associated"| AD_RISK_LOCI
IL6["IL6"] ---|"associated"| AD_RISK_LOCI
ZCWPW1["ZCWPW1"] ---|"associated"| AD_RISK_LOCI| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| PILRB | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| C16ORF95 | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| GMNC | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CR2 | associated_with | gene | 0.60 |
| GENETIC RISK LOCI | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| GMNC | associated_with | gene | 0.60 |
| C16ORF95 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||