protein

PILRB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PILRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections
0Hypotheses
0Analyses
13Outgoing
21Incoming

Summary

PILRB is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Alzheimer, Dementia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPILRB
Chromosome7q22.1.
Protein TypeReceptor
Functionencodes a membrane protein involved in immune cell signaling.
Primary Expressionimmune cells:
Molecular Weight29 kDa
Amino Acids264 aa
Gene TypeProtein Coding
PathwaysPI3K, MAPK pathway
UniProt IDQ9Y5U4
NCBI Gene ID29998
GeneCardsPILRB
Human Protein AtlasPILRB
Gene NamePaired Immunoglobulin-like Type 2 Receptor Beta
DiseaseEvidence Level
Associated DiseasesAlzheimer, Dementia, Ms
InteractionsRGS1, SORL1, CD33, LRRK2, ABCA7, BIN1
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PILRB — AlphaFold Q9Y5U4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

PILRB Gene

gene · 553 words

CR2 (Complement Receptor Type 2)

gene · 1421 words

PILRA Protein

protein · 1248 words

PILRB Protein

protein · 935 words

ZCWPW1 — Zinc Finger CW-Type and PWWP Domain

gene · 695 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    PILRB["<b>PILRB</b>"]
    Alzheimer{"Alzheimer"}
    PILRB -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    PILRB -->|"associated with"| Dementia
    Ms{"Ms"}
    PILRB -->|"associated with"| Ms
    GBA["GBA"]
    PILRB -->|"associated with"| GBA
    CR1["CR1"]
    PILRB -->|"associated with"| CR1
    neurodegeneration["neurodegeneration"]
    PILRB -->|"implicated in"| neurodegeneration
    CR2["CR2"]
    CR2 -->|"associated with"| PILRB
    GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
    GENETIC_RISK_LOCI -->|"associated with"| PILRB
    TREM2["TREM2"]
    TREM2 -->|"associated with"| PILRB
    IL6["IL6"]
    IL6 -->|"associated with"| PILRB
    ZCWPW1["ZCWPW1"]
    ZCWPW1 -->|"associated with"| PILRB
    AD_RISK_LOCI["AD RISK LOCI"]
    AD_RISK_LOCI -->|"associated with"| PILRB
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| PILRB
    CTSH["CTSH"]
    CTSH -->|"associated with"| PILRB
    style PILRB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Dementiaassociated_withdisease0.65
Msassociated_withdisease0.65
GBAassociated_withgene0.60
CR1associated_withgene0.60

Incoming (21)

SourceRelationTypeStr
CR2associated_withgene0.60
TREM2associated_withgene0.60
IL6associated_withgene0.60
ZCWPW1associated_withgene0.60
CTSHassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found