Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PILRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PILRB is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Alzheimer, Dementia, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | PILRB |
| Chromosome | 7q22.1. |
| Protein Type | Receptor |
| Function | encodes a membrane protein involved in immune cell signaling. |
| Primary Expression | immune cells: |
| Molecular Weight | 29 kDa |
| Amino Acids | 264 aa |
| Gene Type | Protein Coding |
| Pathways | PI3K, MAPK pathway |
| UniProt ID | Q9Y5U4 |
| NCBI Gene ID | 29998 |
| GeneCards | PILRB |
| Human Protein Atlas | PILRB |
| Gene Name | Paired Immunoglobulin-like Type 2 Receptor Beta |
| Disease | Evidence Level |
| Associated Diseases | Alzheimer, Dementia, Ms |
| Interactions | RGS1, SORL1, CD33, LRRK2, ABCA7, BIN1 |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PILRB["<b>PILRB</b>"]
Alzheimer{"Alzheimer"}
PILRB -->|"associated with"| Alzheimer
Dementia{"Dementia"}
PILRB -->|"associated with"| Dementia
Ms{"Ms"}
PILRB -->|"associated with"| Ms
GBA["GBA"]
PILRB -->|"associated with"| GBA
CR1["CR1"]
PILRB -->|"associated with"| CR1
neurodegeneration["neurodegeneration"]
PILRB -->|"implicated in"| neurodegeneration
CR2["CR2"]
CR2 -->|"associated with"| PILRB
GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
GENETIC_RISK_LOCI -->|"associated with"| PILRB
TREM2["TREM2"]
TREM2 -->|"associated with"| PILRB
IL6["IL6"]
IL6 -->|"associated with"| PILRB
ZCWPW1["ZCWPW1"]
ZCWPW1 -->|"associated with"| PILRB
AD_RISK_LOCI["AD RISK LOCI"]
AD_RISK_LOCI -->|"associated with"| PILRB
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| PILRB
CTSH["CTSH"]
CTSH -->|"associated with"| PILRB
style PILRB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| GBA | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| RGS1 | interacts_with | gene | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| RET | regulates | gene | 0.60 |
| TREM2 | regulates | gene | 0.60 |
| Alzheimer's disease | regulates | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| macrophages | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CR2 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| PILRA | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| CD33 | regulates | gene | 0.60 |
| CD55 | regulates | gene | 0.60 |
| EPHA1 | regulates | gene | 0.60 |
| PILRA | regulates | gene | 0.60 |
| GENETIC RISK LOCI | associated_with | gene | 0.60 |
| AD RISK LOCI | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||