gene

ZCWPW1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZCWPW1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for ZCWPW1 — Zinc Finger CW-Type and PWWP Domain

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🧬 Gene Info

Gene Symbol	ZCWPW1
Full Name	Zinc Finger CW-Type and PWWP Domain Containing 1
Aliases	Zinc Finger CW-Type and PWWP Domain
Function	ZCWPW1 is a 541 amino acid protein containing CW-type and PWWP domains, which are known to bind to modified histones and participate in chromatin remodeling and gene regulation.[2]
Primary Expression	Moderate expression in brain and peripheral tissues
Molecular Weight	61 kDa
Amino Acids	541 aa
UniProt ID	ZCWPW1
Ensembl ID	ENSG00000060337
GeneCards	ZCWPW1
Human Protein Atlas	ZCWPW1
Chromatin Binding	The CW and PWWP domains recognize specific histone modifications, particularly H3K4me3 and H3K36me3.
Epigenetic Regulation	May function as a reader of histone marks and recruit chromatin-modifying complexes.
Gene Expression	Involved in transcriptional regulation through chromatin interactions.
DNA Repair	Impaired DNA repair is a feature of AD neurons; ZCWPW1 may play a role in neuronal DNA damage response.
Associated Diseases	ALS, Alzheimer, Atherosclerosis, Dementia, Macular Degeneration
Interactions	FERMT2, CELF1, ABCA7, CASS4, EPHA1, CLU
KG Connections	150 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ZCWPW1 — AlphaFold ZCWPW1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ZCWPW1["<b>ZCWPW1</b>"]
    Alzheimer{"Alzheimer"}
    ZCWPW1 -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    ZCWPW1 -->|"associated with"| Dementia
    Ms{"Ms"}
    ZCWPW1 -->|"associated with"| Ms
    AD_RISK_LOCI["AD RISK LOCI"]
    ZCWPW1 -->|"associated with"| AD_RISK_LOCI
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ZCWPW1 -->|"associated with"| ALZHEIMER_S_DISEASE
    CTSH["CTSH"]
    ZCWPW1 -->|"associated with"| CTSH
    PILRB["PILRB"]
    ZCWPW1 -->|"associated with"| PILRB
    GBA["GBA"]
    ZCWPW1 -->|"associated with"| GBA
    CR1["CR1"]
    ZCWPW1 -->|"associated with"| CR1
    neurodegeneration["neurodegeneration"]
    ZCWPW1 -->|"implicated in"| neurodegeneration
    CR2["CR2"]
    CR2 -->|"associated with"| ZCWPW1
    GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
    GENETIC_RISK_LOCI -->|"associated with"| ZCWPW1
    TREM2["TREM2"]
    TREM2 -->|"associated with"| ZCWPW1
    IL6["IL6"]
    IL6 -->|"associated with"| ZCWPW1
    style ZCWPW1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (62)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
ALS	activates	disease	0.65
Macular Degeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
CTSH	associated_with	gene	0.60
PILRB	associated_with	gene	0.60
GBA	associated_with	gene	0.60
CR1	associated_with	gene	0.60
FERMT2	activates	gene	0.60
CELF1	activates	gene	0.60
ABCA7	activates	gene	0.60
CASS4	activates	gene	0.60
EPHA1	activates	gene	0.60
CLU	activates	gene	0.60
BIN1	activates	gene	0.60
CD33	activates	gene	0.60
CD2AP	activates	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
MAF	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
TNF	associated_with	gene	0.60
APOE	activates	gene	0.60
PTK2B	activates	gene	0.60
PPAR	activates	gene	0.60
PILRA	associated_with	gene	0.60
Rb	activates	protein	0.60
AD RISK LOCI	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
LNCRNA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
RNA	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60

Incoming (88)

Source	Relation	Type	Str
CR2	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
IL6	associated_with	gene	0.60
PLD3	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
NME8	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
PILRA	associated_with	gene	0.60
ABCA7	activates	gene	0.60
APOE	activates	gene	0.60
CD2AP	activates	gene	0.60
EPHA1	activates	gene	0.60
CLU	activates	gene	0.60
BIN1	activates	gene	0.60
CASS4	activates	gene	0.60
CD33	activates	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
MAF	associated_with	gene	0.60
PTK2B	activates	gene	0.60
MS4A6A	interacts_with	gene	0.60
PPAR	activates	gene	0.60
CLU	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
MAF	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
EPHA1	interacts_with	gene	0.60
FERMT2	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ZCWPW1

Understanding Entity Pages

Summary

Wiki Pages (10)

ZCWPW1 — Zinc Finger CW-Type and PWWP Domain

Sporadic vs Familial Alzheimer's Disease: Comprehensive Comparison

CR2 (Complement Receptor Type 2)

CELF1 Gene

ZCWPW1 Protein

NME8 Gene

SLC24A4 Gene - Solute Carrier Family 24 Member 4

PILRB Gene